丙型肝炎病毒定量检测结果及相关性因素研究  

Study on the result of hepatitis C virus level and its related factors

作　　者：杨小蓉[1] 丁彩屏[1] 陈小明[1] 秦建川[1] 郭淑珠[1] 

机构地区：[1]广东药学院附属第一医院检验科,广州510080

出　　处：《检验医学与临床》2011年第9期1061-1062,共2页Laboratory Medicine and Clinic

摘　　要：目的比较丙型肝炎患者丙型肝炎病毒（HCV）RNA定量与免疫血清标志物、生化指标丙氨酸氨基转移酶（ALT）、空腹血糖及血液学指标血小板计数检测结果,探讨这几个因素是否相关。方法用荧光定量聚合酶链反应检测101例丙型肝炎患者的血清HCV RNA水平,采用酶联免疫吸附试验检测抗-HCV,采用日立7180全自动生化分析仪检测ALT及血糖,采用全自动血球计数仪检测血小板数量。结果第1组（抗-HCV阳性、HCVRNA〉1 000 U/mL）有33例,ALT高于正常范围（5-40 U）的有12例,占36%,与第2组（抗-HCV阳性、HCVRNA〈1 000 U/mL）ALT阳性率（24%）比较差异有统计学意义（P〈0.05）;空腹血糖高于正常参考范围（3.58-6.1 mmol/L）的有7例,占21%,与第2组空腹血糖阳性率（24%）比较差异无统计学意义（P〉0.05）;血小板计数低于正常范围（100-400×10^9/L）的有4例,占12%,高于正常范围的有0例,与第2组血小板低于正常范围的占33%;高于正常范围的占5.9%比较差异有统计学意义（P〈0.05）。结论 HCV定量值的高低与ALT值,以及糖尿病的发生近似正相关,与血小板计数值近似负相关关系。Objective To study the relationship among the amount of HCV RNA,HCV-Ab,ALT,GLU,and platelet.Methods 101 patients with hepatitis C virus（HCV） were selected,serum level of HCV-Ab、ALT、GLU and platelet were measured.Results The first group： HCV-Ab-positive,HCV RNA〉 1 000 U/mL in 33 cases.ALT exceeds the normal range（5-40 U） in 12 patients.Fasting blood glucose exceeds the normal range（3.58-6.10 mmol/L） in 7 cases.There were 2 cases with the normal range of platelet count（100-400×10^9 / L）.Group 2：There were 68 cases with HCV-Ab-positive and HCV RNA 〈1 000 U/mL,ALT values were abnormal in 16 patients and abnormal fasting glucose exists in 16 cases.Abnormal platelet count took place in 22 cases.Conclusion The value of HCV is related to the value of ALT,and it has a positive relationship with the occurrence of diabetes.But it has a negative correlation with the platelet count.

关 键 词：丙型肝炎病毒 HCVRNA 抗-HCV 丙氨酸氨基转移酶 空腹血糖 血小板 

分 类 号：R512.63[医药卫生—内科学]