脑出血患者急性期血清转铁蛋白及铁蛋白水平的动态变化  

Dynamic changes of serum transferrin and ferritin levels in patients with acute intracerebral hemorrhage

作　　者：魏瑞理[1] 金露[1] 孔慧梅[1] 邹明[1] 林燕[1] 陈卫东[1] 王小同[1] 

机构地区：[1]温州医学院附属第二医院神经内科,325027

出　　处：《浙江医学》2011年第4期511-513,共3页Zhejiang Medical Journal

摘　　要：目的 探讨急性期脑出血患者血清转铁蛋白及铁蛋白水平的动态变化过程及其相关临床意义.方法 分析35例脑出血患者血清转铁蛋白及铁蛋白水平的动态变化并与30例健康体检者进行比较,分析转铁蛋白及铁蛋白水平与脑出血量和NIHSS评分之间的相关性.结果 血清转铁蛋白在脑出血发病后24h内迅速升高（P＜0.05）,第3天达到最高水平（P＜0.05）,随后缓慢下降,发病第7天已接近对照组水平（P ＞0.05）,第14天恢复至正常水平.血清铁蛋白水平在发病2d内无显著变化,然后逐渐上升,在第7天达到高峰水平（P＜0.05）,随后在高水平持续较长时间,在第21天仍较对照组显著升高（P＜0.01）.相关性分析显示脑出血量及NIHSS评分与血清铁蛋白水平（第3天）呈正相关（r=0.654、0.514,均P＜0.01）,但与24h血清转铁蛋白水平无相关性（P ＞0.05）.结论 血清转铁蛋白和铁蛋白参与了脑出血后的病理生理过程,可能与过量铁离子的清除有着密切的联系.Objective To measure serum transferrin （Tf） and ferritin（sFt）levels in patients with acute intracerebral hemorrhage and to investigate its clinical significance. Methods Serum Tf and sFt levels were measured in 35 patients with acute in- tracerebral hemorrhage during different phases （within 24 h, at 3, 7,14 and 21d after the onset of disease） and 30 healthy sub- jects （control group）. The correlation of Tf and sFt levels with cerebral hemorrhage volume and NIHSS score were analyzed. Results Serum Tf levels increased rapidly （P〈 0.05） after the onset of acute intracerebral hemorrhage and reached the peak at d3, then decreased gradually and returned to normal level at d14. Serum ferritin level did not changed significantly during the first 2 days and then increased gradually, reached the peak at d7 and kept high level at d21 （P〈 0.05）. Intracerebral hemorrhage volume and NIHSS scores were positively correlated with serum ferritin levels on 3d （r=0.654,0.514,P〈0.01）,but not with serum Tf levels at 24h. Conclusion Serum transferrin and ferritin are involved in the pathophysiological process of intracerebral hemorrhage, which may be related to the removal of excess iron after ICH.

关 键 词：脑出血 转铁蛋白 铁蛋白 铁离子 

分 类 号：R459.3[医药卫生—治疗学]