血清胱抑素C与β2微球蛋白、尿微量清蛋白检测在2型糖尿病肾病早期诊断中的相关研究  

Discussin of Cystatin C and β2-MG, Malbassay in the Diagnosis of Earlyrenal Damage in Type 2 DM

作　　者：谈昀[1] 李军民[1] 曾宪飞[1] 张树苗[1] 

机构地区：[1]武警陕西总队医院检验科,西安710054

出　　处：《现代检验医学杂志》2011年第2期107-108,111,共3页Journal of Modern Laboratory Medicine

摘　　要：目的 与血β2微球蛋白（β2-MG）、尿微量清蛋白（mAlb）比较,评价血清胱抑素C（Cysctatin C）测定在2型糖尿病（DM）肾病早期诊断中的研究价值.方法 对120名健康人及246例2型糖尿病患者的Ccr,Cysctatin C,β2-MG,尿mAlb测定结果进行平均值、相关性、敏感度比较分析.2型糖尿病患者按Ccr水平分为DM1组（Ccr≥80 ml/min 1.73 m^2,102例）、Dm^2组（80 ml/min 1.73 m^2〉Ccr≥50ml/min 1.73 m^2,144例）.结果 DM1组各指标平均值与对照组相比差异无统计学意义,Dm^2组与对照组相比差异有统计学意义（P＜0.01）;各组结果具有良好的相关性,Cysctatin C与Ccr相关系数分别为-0.885,-0.550,-0.680,Cysctatin C与β2-MG相关系数分别为0.893,0.721,0.897,Cysctatin C与尿mAlb相关系数分别为0.823,0.676,0.852;各指标中血Cysctatin C测定最为敏感（DM1组47.1%,Dm^2组81.2%）.结论 血Cysctatin C测定为2型糖尿病肾病患者早期诊断的理想指标,在常规Scr,Ccr检测的同时联合应用Cysctatin C检测可减低糖尿病肾病的漏诊率.Objective To compare β2-MG and mAlb and assess the clinical value in the detection of Cystatin C in the diagnosis of early renal damage of type 2 DM. Methods Detected the Ccr,Cystatin C,β2-MG and mAlb of 120 healthy persons and 246 cases of type 2 DM and analyzed the average value,correlation and sensitivity of the results. Cases with type 2 DM were divided into DM1 group （Ccr≥80 ml/min 1.73 m^2,102 cases） and DM2 group（80 ml/min 1.73 m^2〉Ccr≥50 ml/min 1.73 m^2,144 cases） according to their Ccr level. Results There was no statistical significance of the average value in DMlcomparing with the contrast group, while there was significant difference in DM2 comparing with the contrast group （P〈0. 01） ;the result of each group had good correlation,the correlation coefficients of Cystatin C and Ccr were - 0. 885,-0. 550 and -0. 680;Cystatin C andβ2-MG were 0. 893,0. 721 and 0. 897;Cystatin C and mAlb were 0. 823,0. 676 and 0. 852 respectively. Among the index,Cys-tatin C detection was most sensitive （46.1% in DM 1,80.6% in DM2）. Conclusion Cystatin C detection is ideal in diagnosing early renal damage of type 2 DM. Combining the regular Scr,Ccr detection with Cystatin C detection,the omission diagnoserate of diabetic nephropathy can be decreased.

关 键 词：胱抑素C Β2微球蛋白 尿微量清蛋白 早期肾损害 

分 类 号：R587.1[医药卫生—内分泌] R446.112[医药卫生—内科学]