血浆（1,3）-β-D-葡聚糖检测对老年人深部真菌感染的诊断价值  

Diagnostic Value of Plasma β-Glucan Detection for Deep Fungal Infection in the Elderly

作　　者：杨艳兵[1] 李从荣[1] 郝世勇[1] 李娟[1] 余华[1] 

机构地区：[1]武汉大学人民医院检验科,武汉430060

出　　处：《现代检验医学杂志》2011年第2期130-132,共3页Journal of Modern Laboratory Medicine

摘　　要：目的 探讨血浆（1,3）-β-D-葡聚糖（BG）检测（G试验）对老年人深部真菌感染的诊断价值.方法 采用动态比浊法检测67例老年高危患者的血浆BG浓度,并与真菌培养结果进行比较.结果 67例高危患者,G试验31（46.27%）例阳性,真菌培养法21（31.34%）例阳性.深部真菌感染组血浆BG中位数浓度为45.97 pg/ml;非真菌感染组浓度为5.00 pg/ml,两组差异有统计学意义（Z=-6.138,P＜0.01）.若以真菌培养为标准,G试验的敏感度、特异度、阳性预测值和阴性预测值分别为90.48%,73.91%,61.29%和94.44%.结论 G试验对于老年人深部真菌感染具有早期、快速的诊断价值.Objective To analyse the diagnostic value of plasma （1,3）-β-D-glucan （BG） assay （G-test） for oldsters who suffer deep fungal infection. Methods The concentrations of serum BG were detected with the kinetic turbidimetric method in 67 elderly high-risk patients,and compared with the results of fungal culture. Results There were 31（46. 27%） positive samples identified by G test and 21（31.34%） positive samples identified by fungal culture in 67 patients who were suspected deep mycosis. The median concentration of serum BG in the deep fungal infection group was 45.97 pg/ml,while it was 5.00 pg/ml in the non-infected group. There were statistically differences between the two groups （Z =- 6. 138,P〈 0. 01）. When fungal culture was applied as the standardization of diagnosing deep fungal infection,the sensitivity,specificity,positive and negative predictive values of G-test were 90. 48%, 73.91% ,61.29% and 94. 44% ,respectively. Conclusion G-test is a valuable method which could rapidly diagnose the deep fungal infection in the elderly in the early phase.

关 键 词：(1 3)-β-D-葡聚糖 真菌 老年人 

分 类 号：R519[医药卫生—内科学] R446.62[医药卫生—临床医学]