尿肾功早期损害检测指标在慢性肾病诊断、监测中的应用  

Utility of Laboratory Examination on Chronic Kidney Disease with Earlier Early Diagnosis and Monitoring of Kidney Damage Criterion Analysis

作　　者：高军[1] 张婧[1] 张静[1] 马巍[1] 程芳[1] 李倩[1] 赵绒[1] 黄晶[1] 韦三华[1] 张惠中[1] 

机构地区：[1]第四军医大学唐都医院临床实验与检验、输血科,西安710038

出　　处：《现代检验医学杂志》2011年第2期144-146,共3页Journal of Modern Laboratory Medicine

摘　　要：目的 检测慢性肾病尿肾功早期损伤指标,探讨其在慢性肾病诊断及监测中的意义.方法 将155例经肾穿刺确诊的肾病患者根据病因分组,检测其尿中微量清蛋白（MA）、α1-微球蛋白（α1-M）、β2-微球蛋白（β2-M）、转铁蛋白（TRF）、免疫球蛋白G（IgG）、轻链κ、轻链λ,观察其升高情况,同时进行患者尿蛋白和血中尿素氮（BUN）、肌酐（Cr）和尿酸（UA）浓度检测,比较其诊断及监测意义.结果 五类慢性肾病患者尿中早期肾损害指标均明显高于正常对照组（P〈0.01）,而常规肾功测定,与对照组无明显差异（P〉0.05）;肾功能早期损害指标与患者肾病严重程度呈正相关.结论 尿肾功早期损伤指标对于肾病的早期诊断和疾病监测均具有重要意义.Objective To investigate the significance of diagnosis and monitoring in chronic kidney disease by detecting earlier kidney damage criterion. Methods 155 cases of chronic kidney disease patients definite by kidney puncturation were grouping, MA, α^1-M ,β^2-M, TRF, IgG, κ and λ, were detected in the urine, BUN, Cr and UA were analysised in serum as the same time. Results The results of earlier kidney damage criterion were higher than that of the normal control （P〈0.01）, however there was no significant difference in analysis of BUN,Cr and UA between the chronic kidney disease patients and normal controls （P〉0. 05）. The increasing degrees were associated with the severity of the kidney disease. Conclusion There was significance in diagnosis and disease surveillance by detecting of the urine earlier kidney damage criterion.

关 键 词：肾功能早期损害 慢性肾病 诊断 

分 类 号：R692[医药卫生—泌尿科学] R446.112[医药卫生—外科学]