Mechanical behavior of the erythrocyte in microvessel stenosis  

作　　者：ZHANG ZhiGuo ZHANG XiWen 

机构地区：[1]State Key Laboratory of Structural Analysis for Industrial Equipment, Dalian University of Technology, Dalian 116024, China [2]School of Aerospace, Tsinghua University, Beijing 100084, China

出　　处：《Science China(Life Sciences)》2011年第5期450-458,共9页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China (Grant No.10672090);the National High Technology Research and Development Program of China (Grant No.2006AA02Z4E8)

摘　　要：The passage of red blood cells （RBCs） through capillaries is essential for human blood microcirculation. This study used a moving mesh technology that incorporated leader-follower pairs to simulate the fluid-structure and structure-structure interac- tions between the RBC and a microvessel stenosis. The numerical model consisted of plasma, cytoplasm, the erythrocyte membrane, and the microvessel stenosis. Computational results showed that the rheology of the RBC is affected by the Reynolds number of the plasma flow as well as the surface-to-volume ratio of the erythroeyte. At a constant inlet flow rate, an increased plasma viscosity will improve the transit of the RBC through the microvessel stenosis. For the above reasons, we consider that the decreased hemorheology in microvessels in a pathological state may primarily be attributed to an increase in the number of white blood cells. This leads to the aggregation of RBCs and a change in the blood flow structure. The present fundamental study of hemorheology aimed at providing theoretical guidelines for clinical hemorheology.The passage of red blood cells (RBCs) through capillaries is essential for human blood microcirculation.This study used a moving mesh technology that incorporated leader-follower pairs to simulate the fluid-structure and structure-structure interactions between the RBC and a microvessel stenosis.The numerical model consisted of plasma,cytoplasm,the erythrocyte membrane,and the microvessel stenosis.Computational results showed that the rheology of the RBC is affected by the Reynolds number of the plasma flow as well as the surface-to-volume ratio of the erythrocyte.At a constant inlet flow rate,an increased plasma viscosity will improve the transit of the RBC through the microvessel stenosis.For the above reasons,we consider that the decreased hemorheology in microvessels in a pathological state may primarily be attributed to an increase in the number of white blood cells.This leads to the aggregation of RBCs and a change in the blood flow structure.The present fundamental study of hemorheology aimed at providing theoretical guidelines for clinical hemorheology.

关 键 词：red blood cell moving mesh leader-follower pair RHEOLOGY fluid-structure interaction 

分 类 号：Q631[生物学—生物物理学] Q959.836