血中安非拉酮的薄层色谱扫描检测研究  

Identification of amfepramone in serum by TLC Scan

作　　者：贠克明[1] 郑金平[1] 李贵明[1] 赵景春 

机构地区：[1]山西医科大学,太原030001 [2]山西闻喜县公安局,043800

出　　处：《中国法医学杂志》1999年第3期145-147,共3页Chinese Journal of Forensic Medicine

摘　　要：建立血中安非拉酮的快速检测方法。用环已烷或氯仿提取，薄层层析分离，薄层扫描定性和定量检测。结果显示：血清中安非拉酮的线性检测范围为0．2～12μm／ml，最小检出浓度为0．1μg／ml。2例服药过量患者血清中安非拉酮含量为3．2mg／L和4．7mg／L。本法可用于安非拉酮中毒的快速诊断和安非拉酮中毒的法医学鉴定。The purpose of the presents study is to establish rapid qualitative and quantitative analysis of amfepramone in huamn serum. The amfepramone was extracted with trichloromethane or ethylacetate, and separated with TLC, and was detected with TLC scan. The extraction curves of amfepramone in serum was liner over the range of 0.2 to 12μg/ml. The limit of detection was 0. 1μg/ml. The amfepramone detected in two amfepramone overdosed cases were 3. 2mg/L and 4. 7mg/L. This analytic method is simply,more sensitive, and practical. The method can be used for amfepramone detection in case of overdosing and poisoning identification.

关 键 词：安非拉酮 薄层色谱扫描 药物中毒 法医鉴定 

分 类 号：R595.404[医药卫生—内科学] D919.2[医药卫生—临床医学]