矽肺患者一氧化氮和抗氧化剂浓度检测及其临床意义  

Measurement of the Concentrations of Nitric Oxide and Antioxidants of Silicotic Patients and Its Clinical Significance

作　　者：周君富[1] 朱永平[2] 吴丹参[3] 彭芬英[1] 丁德云[1] 

机构地区：[1]浙江医科大学附属第二医院,杭州310009 [2]浙江医科大学毒理研究室 [3]浙江省杭州市职业病防治院

出　　处：《工业卫生与职业病》1999年第5期264-268,共5页Industrial Health and Occupational Diseases

摘　　要：为探讨矽肺与一氧化氮和抗氧化剂的关系， 我们检测了７３ 例矽肺患者和６０ 例健康对照者血浆中的一氧化氮（Ｐ－ ＮＯ） 、维生素Ｃ （Ｐ－ ＶＣ） 、维生素Ｅ（Ｐ－ ＶＥ） 、β－ 胡萝卜素（Ｐ－ β－ ＣＡＲ） 浓度。结果表明， 与对照组比较， 患者组的Ｐ－ ＮＯ 平均浓度显著升高， Ｐ－ ＶＣ、Ｐ－ ＶＥ、Ｐ－ β－ ＣＡＲ 平均浓度均显著降低（ Ｐ＜ ０－００１） ； 各检测值与患者病程、病情、肺功能状态均有相关； 逐步回归表明， 患者病程、病情、肺功能状态与Ｐ－ ＮＯ、Ｐ－ ＶＥ 相关最密切。提示矽肺患者一氧化氮代谢异常， 氧化抗氧化平衡严重失调。In orderto probeinto the correlation between nitric oxide, antioxidantsand silicosis, concentrations of nitric oxide (P- NO) , vitamin C (P- VC) , vitamin E (P- VE) and beta carotene (P- β- CAR) in plasma of 73 silicotic patients and 60 healthy subjects were measured .Resultsshowed thatin comparing with the control group ,the average P- NOconcentration of the patient group wassignificantly increased ( P< 0-001) , and the average P- VC, P- VE, P- β-CARconcentrations of the patient group were significantly lowered ( P< 0-001) , All the valuesmeasured were correlated with the course, condition and pulmonary function ofthe silicotic patients. The stepwise regression showed that very close correlation existed between the course, condition andpulmonary function ofthe patients and the concentrations of P- NOand P- VE. It suggested thatthe metabolism of nitric oxide ofsilicotic patientsappeared abnormal, andthe balance between oxida tion and antioxidation wasseriously disturbed .

关 键 词：矽肺 一氧化氮 维生素C 维生素E 检测 

分 类 号：R135.2[医药卫生—劳动卫生]