A population-based case-crossover study of polyethylene glycol use and acute renal failure risk in the elderly  

作　　者：Nam-Kyong Choi Yoosoo Chang Sun-Young Jung Yu-Kyong Choi Joongyub Lee Jin-Ho Lee Ju-Young Kim Byung-Joo Park 

机构地区：[1]Department of Preventive Medicine,Seoul National University College of Medicine,Seoul 110-799,South Korea [2]Medical Research Center,Seoul National University,Seoul 110-799,South Korea [3]Department of Occupational Medicine,Health Screening Center,Kangbuk Samsung Hospital,Sungkyunkwan University College of Medicine,Seoul 110-746,South Korea [4]National Evidence-Based Healthcare Collaborating Agency,Seoul 110-450,South Korea [5]Department of Internal Medicine,Gumi Hospital,Gumi 730-909,South Korea [6]Medical Research Collaborating Center,Seoul National University Hospital [7]Seoul National University College of Medicine,Seoul 110-799,South Korea [8]Department of Internal Medicine,Dongguk University Ilsan Hospital,School of Medicine,Dongguk University,Goyang 410-733,South Korea [9]Department of Family Medicine,Health Promotion Center,Seoul National University Bundang Hospital,Bundang 463-707,South Korea

出　　处：《World Journal of Gastroenterology》2011年第5期651-656,共6页世界胃肠病学杂志（英文版）

摘　　要：AIM:To evaluate the possibility of an association between polyethylene glycol(PEG) and acute renal failure(ARF) in elderly patients using a health insurance claims database.METHODS:We conducted a population-based casecrossover study using information obtained from Korean Health Insurance Review and Assessment Service(HIRA) claims from January 1,2005 to December 31,2005(Seoul,Korea).The study population consisted of elderly patients who received PEG prior to experiencing their first ARF-related hospitalization from April 1,2005 to December 31,2005.For each patient,one case and two control periods were matched.PEG use in a 2-or 4-wk window period prior to hospitalization for ARF was compared with PEG use in two earlier 2-or 4-wk control window periods.Conditional logistic regression analysis was used to estimate odds ratios(ORs) and 95% CI,adjusting for concomitant uses of diuretics,angiotensin converting enzyme inhibitors,non-steroidal anti-inflammatory drugs,antibiotics,anti-cancer drugs,and contrast media.RESULTS:Within the HIRA database which contained 1 093 262 elderly patients,1156 hospitalized ARF cases were identified.Among these cases,PEG was prescribed to 17(1.5%) patients before hospitalization.The adjusted ORs when applying the 2-and 4-wk window periods were 0.4(95% CI:0.03-5.24) and 2.1(95% CI:0.16-27.78),respectively.CONCLUSION:No increased risk of ARF was found in elderly PEG users.However,based on the limited number of study subjects,further analysis should be performed to confirm these results.AIM： To evaluate the possibility of an association be-tween polyethylene glycol （PEG） and acute renal failure （ARF） in elderly patients using a health insurance claims database. METHODS： We conducted a population-based casecrossover study using information obtained from Korean Health Insurance Review and Assessment Service （HIRA） claims from January 1, 2005 to December 31, 2005 （Seoul, Korea）. The study population consisted of elderly patients who received PEG prior to experiencing their first ARF-related hospitalization from April 1, 2005 to Decem- ber 31, 2005. For each patient, one case and two control periods were matched. PEG use in a 2- or 4-wk window period prior to hospitalization for ARF was compared with PEG use in two earlier 2- or 4-wk control window periods. Conditional logistic regression analysis was used to estimate odds ratios （ORs） and 95% CI, adjusting for concomitant uses of diuretics, angiotensin converting enzyme inhibitors, non-steroidal anti-inflammatory drugs, antibiotics, anti-cancer drugs, and contrast media. RESULTS： Within the HIRA database which contained 1093 262 elderly patients, 1156 hospitalized ARF cases were identified. Among these cases, PEG was prescribed to 17 （1.5%） patients before hospitalization. The adjusted ORs when applying the 2- and 4-wk window periods were 0.4 （95% CI： 0.03-5.24） and 2.1 （95% CI： 0.16-27.78）, respectively. CONCLUSION： No increased risk of ARF was found in elderly PEG users. However, based on the limited number of study subjects, further analysis should be performed to confirm these results.

关 键 词：Polyethylene glycol Acute renal failure Adverse drug reaction Health insurance claims data-base CASE-CROSSOVER 

分 类 号：R595.3[医药卫生—内科学] R692.5[医药卫生—临床医学]