HPLC和UV法测定参麦注射液与果糖注射液的配伍稳定性  

Study on the compatible stability of shenmai injection with fructose injection by HPLC and UV

作　　者：陈旭秀 

机构地区：[1]浙江省泰顺县人民医院,泰顺325500

出　　处：《海峡药学》2011年第5期27-28,共2页Strait Pharmaceutical Journal

摘　　要：目的测定参麦注射液与果糖注射液的配伍稳定性。方法模拟临床浓度和使用方法,采用HPLC和UV法测定参麦注射液与果糖注射液配伍后的含量变化,同时测定溶液的pH值,观察溶液的颜色及澄明度的变化。结果参麦注射液与果糖注射液配伍后,UV光谱和pH值、颜色、澄明度在24h内均无明显变化,但HPLC谱不稳定。结论参麦注射液与果糖注射液的配伍需要进一步的研究,临床配伍使用应慎重。OBJECTIVE To study the compatible stability of shenmai injection with fructose injection.METHODS The pH value of the solution was tested,the solution content was determined by HPLC and UV,the colour and clarity was observed to study the stability of shenmai injection with fructose injection.RESULTS The UV and pH was no significant changes after matching for 24 hours.But change of HPLC after 4 hours.CONCLUSION It will be unstable for the shenmai injection with fructose injection.Clinical use should be prudent.

关 键 词：参麦注射液 果糖注射液 配伍 稳定性 

分 类 号：R927.2[医药卫生—药学]