长期服用盐酸苯海索治疗对精神分裂症患者认知功能的影响  

Effects of long-term benzhexol use on cognitive function in schizophrenia patients

作　　者：刘建君[1] 李雪梅[1] 

机构地区：[1]浙江湖州市第三人民医院,湖州313000

出　　处：《海峡药学》2011年第5期99-101,共3页Strait Pharmaceutical Journal

摘　　要：目的探讨盐酸苯海索抗胆碱治疗对精神分裂症认知功能的影响。方法服用第二代抗精神病药合并盐酸苯海索治疗大于3月的60名精神分裂症病人按照服药种类配对分为研究组和对照组各30名,研究组在4周内逐渐停用盐酸苯海索,对照组盐酸苯海索剂量保持不变,分别在基线和一月后进行威斯康星卡片分类测验(WCST)、霍普金斯词汇学习测验(HVLT-R)、持续操作功能测定(CPT)、韦克斯勒记忆测定(WMS)、阴性症状和阳性症状量表(PANSS)、锥体外系反应量表(ESRS)测定。结果研究组患者均安全停用盐酸苯海索,研究组停药前后认知功能评分存在显著性差异(P<0.05)。两组阴性症状和阳性症状量表(PANSS)、锥体外系反应量表(ESRS)评分无显著性差异(P>0.05)。结论长期服用盐酸苯海索对服用第二代抗精神病药的精神分裂症病人认知功能有不良影响,逐渐停药是安全的,停药后患者的认知功能有明显改善。OBJECTIVE The aim of this study was to evaluate the effects of gradual discontinuation of benzhexol on cognitive function in schizophrenia.METHODS 60 schizophrenic patients who had received a second-generation antipsychotic（SGA） with concomitant for at least 3months were assigned to reseach group（n=30） and control group（n=30）.Study Group phased out benzhexol within 4 weeks,while control group remained unchanged.Before and 1month after discontinuation of benzhexol,were administered.Clinical evaluation also included the Positive and Negative Syndrome Scale（PANSS）,Wisconsin card sorting test（WCST）,Continuous performance test（CPT）,Wechsle memory scale（WMS）.RESULTS Benzhexol was discontinued safely in patients of reseach group,and no emergent extrapyramidal symptoms were observed.study group improved significantly in cognitive funcition.CONCLUSION Discontinuation of long-term benzhexol use may be warranted in patients with schizophrenia treated with SGAs,as it may improve cognitive function without significant adverse effects.

关 键 词：盐酸苯海索 第二代抗精神病药 精神分裂症 认知功能 

分 类 号：R969.4[医药卫生—药理学]