P-选择素/P-选择素糖蛋白配体-1与骨髓祖细胞胸腺归巢  

P-selectin/PSGL-1 and homing of bone marrow-derived progenitors to thymus

作　　者：张琳[1] 郝选明[2] 邓树勋[2] 肖鹏[1] 

机构地区：[1]华南师范大学生命科学学院,广州510631 [2]华南师范大学体育科学学院,广州510631

出　　处：《天津师范大学学报（自然科学版）》2011年第2期77-81,共5页Journal of Tianjin Normal University：Natural Science Edition

基　　金：广东省自然科学基金资助项目(9151063101000059)

摘　　要：骨髓衍生的祖细胞归巢入胸腺是T细胞发育必需的过程,因为胸腺不包含具有自我更新能力的造血干细胞,它需要从血液中添补祖细胞,此过程依赖多级细胞粘附分子和趋化因子的衔接.细胞粘附分子选择素和它的配体PSGL-1在淋巴样祖细胞归巢入胸腺的过程中发挥重要作用.综述了选择素/配体PSGL-1的生物学特征及其相互作用对骨髓祖细胞胸腺归巢及胸腺-骨髓反馈环的影响和作用机制.Homing of bone marrow（BM）-derived progenitors to the thymus is essential for T cell development,because the thymus does not contain hematopoietic stem cells（HSC） with unlimited self-renewing capacity,it needs to recruit progenitors from the blood.The process is considered to depend on the multistep engagement of adhesion molecules and chemoattractants.This cascade involves selectin and its ligand interactions,signaling of chemokine through its receptor,and activation-induced binding of the integrins to their respective ligands.P-selectin/PSGL-1 play a significant role.The biological characterization of P-selectin/PSGL-1 and the effects on homing of bone marrow-derived progenitors to the thymus and thymus-bone marrow feedback loop of P-selectin/PSGL-1 interaction are summarized.

关 键 词：P-选择素/P-选择素糖蛋白配体-1 骨髓 祖细胞归巢 胸腺 

分 类 号：R392.1[医药卫生—免疫学]