大鼠创伤性脑水肿一氧化氮及其合成酶的变化  

Changes in nitric oxide and nitric oxide synthase in rats with traumatic cerebral edema

作　　者：戢翰升[1] 王小菊[1] 简志宏 赵斌杰[1] 

机构地区：[1]湖北省十堰市人民医院神经外科,湖北十堰442000

出　　处：《中国危重病急救医学》1999年第10期622-623,共2页Chinese Critical Care Medicine

基　　金：湖北省十堰市科技重点项目

摘　　要：目的：探讨脑损伤后一氧化氮（ＮＯ）及一氧化氮合酶（ＮＯＳ）与脑水肿的关系。方法：建立大鼠创伤性脑水肿模型，按不同时间点处死动物，测定其脑含水量及静脉血ＮＯ 和脑组织中ＮＯＳ。结果：脑创伤后脑含水量随静脉血ＮＯ的增加而增加，组织ＮＯＳ则随ＮＯ 的增加而下降。结论：创伤性脑水肿与血ＮＯ 有密切相关性。Objective:To investigate the potential relationship between local nitric oxide (NO),nitric oxide synthase (NOS) and cerebral edema after brain injury.Methods:A rat model of traumatic cerebral edema was produced in the present study,and cerebral water content,plasma NO level,as well as cerebral NOS activity were determined in rats at various intervals.Results:After brain injury,cerebral water contents markedly increased along with elevation of plasma NO levels,while cerebral NOS activities decreased when plasma NO levels were elevated.Conclusions:It is suggested that traumatic cerebral edema appears to be associated with circulating NO release,and local NOS may be a “catalyst” involoved in this process.

关 键 词：脑水肿 一氧化氮 一氧化氮合酶 创伤 病理 

分 类 号：R651.150.2[医药卫生—外科学]