布比卡因加芬太尼硬膜外阻滞对分娩的影响  

Influence of Bupivacaine Hydrochloride and Fentanyl Citrate for Lumbar Epidural Anesthesia on Women in Labour

作　　者：程凤仙[1] 程忠[1] 周敦诗[1] 江丽红 郑满荣[1] 叶毅玲[1] 杨学娅[1] 

机构地区：[1]海军安庆医院妇产科,安庆246003

出　　处：《南京军医学院学报》1999年第3期154-157,共4页Journal of Nanjing Military Medical College

摘　　要：目的：探讨低剂量布比卡因加芬太尼硬膜外阻滞镇痛对分娩的影响。方法：用0．125％布比卡因加芬太尼2．5μg／ml硬膜外阻滞镇痛的69例初产妇为镇痛组，与未行镇痛术69例同等条件的初产妇对照，用随机单盲方法进行临床观察。结果：低剂量布比卡因与芬太尼联合用药使硬膜外阻滞镇痛有效率达100％，并改善它缩性质，协调宫缩即缩短活跃期宫缩持续时间；松弛盆底肌肉，减轻抬头下降受阻，加速宫口开大及胎头下降（P＜0．01），缩短活跃期及第二产程（P＜0．01），减少胎儿宫内窘迫、产生出血及难产率。结论：0．125％布比卡因加芬太尼2．5μg／ml用于硬膜外阻滞镇痛是一种安全、有效无痛分娩术。Objective To explore the iaflunce of low-dose bupivacaine hydrochloride and fentanyl citrate for lumbar epidural anesthesia on women in labour. Methods: Sixty-nine prindparea used bupivacaine hydrochloride (0. 125%) and Fentanyl citrate (2.5 μg/ml) for analgesia during the labour as study group. Another 69 primiparea did not use any drugs as control group. A randomized single-blind method was used for clinical observation. Results: The effective rate of analgesia with low-dose bupivacaine hydrochloride and fentanyl citrate for epidural block was 100%. Epidural block could improve uterine contractions, coordinate the activity of uterine contractions (i. e. shorten the duration of uterine contractions during the active stage), relax pelvis floor muscles, lessen the pressure on descending of fetal head, accelerate the opening of ostium uteri and the descending of fetal head (P < 0.01), shorten the active stage and the second stage of labour(P <0.01), so as to reduce the incidence of fetal distress,postpartum hemorrhage and dystocia. Conclusion: Epidural anesthesia for analgesia with bupivacaine hydrochloride (0. 125%) and Fentanyl citrate (2 .5μg/ml) is a safe, effective and painless labour.

关 键 词：硬膜外阻滞 无痛分娩 镇痛 布比卡因 芬太尼 

分 类 号：R714.3[医药卫生—妇产科学]