原发性高血压患者补体C3水平与血管结构和功能的关系研究  

Study on relationship between serum level of complement C3 and arterial structure and function in patients with essential hypertension

作　　者：王泰蓉[1] 李燕[2] 汤宜婷[1] 杨春华[1] 郭淑杰[2] 

机构地区：[1]上海交通大学医学院附属瑞金医院卢湾分院急诊科 [2]上海市高血压研究所,上海200025

出　　处：《临床和实验医学杂志》2011年第9期644-646,共3页Journal of Clinical and Experimental Medicine

基　　金：上海市自然科学基金项目(08ZR1422000);上海市教委项目(09YZ101);上海市卢湾区科学技术委员会医疗卫生科研项目(LKW0805)资助

摘　　要：目的观察原发性高血压患者补体C3水平并分析其与血管结构和功能的相关性。方法连续入选2008年3月至2010年3月就诊的未经抗高血压药物治疗的原发性高血压患者46例,按照血清补体C3水平、分为高C3组27例,低C3组19例。测定平均颈总动脉内膜中膜厚度(IMTmean)和颈动脉-股动脉脉搏波传导速度(cfPWV)。结果与低C3组比较,高C3组患者年龄较大,收缩压(SBP)、三酰甘油(TG)和载脂蛋白B(APO-B)较高(P<0.05)。高C3组cfPWV和IMTmean高于低C3组(P<0.05)。在校正了年龄、性别、吸烟史、血脂谱、血糖后进行偏相关分析,补体C3与cfPWV仍呈显著正相关(r=0.367,P=0.025),与SBP亦显著相关(r=0.251,P=0.005),与IMTmean没有明显的相关性(r=0.179,P=0.269)。结论原发性高血压患者的补体C3水平与PWV相关,可作为PWV的独立预测因子。补体C3可能参与了高血压患者动脉僵硬度增加的病理过程。Objective To study the relationship between serum level of complement C3 and arterial structure and function in patients with essential hypertension.Methods Forty-six consecutive outpatients with essential hypertension without drug treatment during March 2008 to March 2010 were allocated into high C3 level group and low C3 level group according to their serum levels of C3.There were 27 patients in high C3 level group and 19 in low C3 level group.The mean of carotid intimate-media thickness（IMTmean） and carotid-femoral pulse wave velocity（cfPWV） were determined.Results Patients in high C3 level group were older in age with higher levels of systolic blood pressure（SBP）,triglycercide（TG） and apolipoprotein B（APO-B） in comparison with those of low C3 level group（P0.05）.After adjusting the factors of age,sex,history of smoking,lipid spectrum and glucose,there was positive correlation between serum level of C3 and cfPWV（r=0.367,P=0.025） and also between serum level of C3 and SBP（r=0.251,P=0.005） by partial correlation analysis.However,serum level of C3 was not significantly correlated to IMTmean（r=0.179,P=0.269）.Conclusion The serum level of complement C3 is positively correlated with cfPWV in patients with essential hypertension,and it can be used as an independent predictor.This study suggested that complement C3 may be involved in pathological process in development of higher arterial stiffness in patients with essential hypertension.

关 键 词：原发性高血压 补体C3 颈动脉内膜中膜厚度 脉搏波传导速度 

分 类 号：R544.1[医药卫生—心血管疾病]