抑制β2肾上腺素受体过度激活对被动吸烟大鼠肺组织病理改变的影响  

Effect of inhibition of β2-adrenalin receptor overactivation on the pathological changes in smoking rat emphysema models

作　　者：李继红[1] 贺蓓[1] 王伟[1] 牛黎明[1] 王玉柱[1] 裴斐[2] 

机构地区：[1]北京大学第三医院呼吸科,100083 [2]北京大学医学部病理学系,100083

出　　处：《国际呼吸杂志》2011年第9期663-667,F0003,共6页International Journal of Respiration

基　　金：基金项目：国家自然科学基金（30770939）

摘　　要：目的使用β肾上腺素受体阻断剂抑制被动吸烟大鼠动物模型β2肾上腺素受体的过度激活，观察其肺功能、小气道病理及肺气肿改变。方法雄性SD大鼠随机分为正常对照组（9只），吸烟组（8只）和吸烟＋β肾上腺素受体阻断剂干预组（简称吸烟＋干预组，8只）。对各组进行肺功能测定，同时测定小气道病理评分和平均肺泡线性间隔。结果吸烟＋干预组PEF与吸烟组PEF相比，差异无统计学意义[（7．85±0．53）ml／sVS（7．54±1．41）ml／s]（P〉0．05）；小气道病理总评分吸烟＋干预组与吸烟组相比，差异有统计学意义[（14．43±7．16）分VS（23．00±7．19）分]（P〈0．05），主要表现为小气道阻塞和杯状细胞化生；平均肺泡线性间隔吸烟＋干预组与吸烟组相比，差异有统计学意义[（39．47±2．56）／zmVS（47．46±4．98）um]（P〈0．01）。结论抑制交感神经过度活化和口。肾上腺素受体过度激活可以明显改善小气道病理总评分，减轻杯状细胞化生，减少黏液分泌，改善小气道阻塞，并减轻肺气肿，对肺功能无显著影响。Objective We use unselective β- adrenalin receptor blocker to inhibit the overactivation of sympathetic nerves and β2-adrenalin receptor on smoking-rat, and measure their lung function, observe the pathological changes of the small airway, the mean lung liner intercept. Methods Male SD rat were randomly divided into normal control group（ n = 9）, smoking group（ n = 8）, smoking ＋ propronol group （ n =8）. We tested every rat＇s lung function, did histologicai analysis of the lungs and assess the small airway. We also measured the mean linear intercept. Results The PEF of the smoking ＋propronol group were not significant changed compared with those of smoking group [（ 7.85 ± 0.53）ml/s vs （7. 54±1.41） ml/s]（ P 〉0.05）. The total grades of small airway pathology of the smoking ＋propronol group were obviously decreased compared to the smoking group[ （14.43 ± 7.16） scores vs （23.00 ± 7.19） scores] （ P 〈 0.05）, especially the obstruction of sinall airway and metaplasia of goblet cell. The mean linear intercept of the smoking ＋ propronol group were also alleviated significantly comparing to the smoking group[（39.47±2.56） um vs （47.46±4.98） um ]（ P 〈0.01）. Conclusions The inhibition of over-activation of sympathetic nerves and β2-adrenalin receptor can alleviate airway pathological changes and improve emphysema, but have no influence on lung function.

关 键 词：被动吸烟大鼠模型 Β2肾上腺素受体 小气道病理改变 肺气肿 

分 类 号：R563.9[医药卫生—呼吸系统]