动态血糖仪持续监测联合胰岛素泵强化治疗继发性磺脲类失效血糖水平的漂移变化  

Continuous glucose monitoring combined subcutaneous insulin in subjects with secondary sulfonylureas failure

作　　者：唐奇志 陈聪 张燕华 

机构地区：[1]广东省中西医结合医院,广东佛山528200

出　　处：《中国现代医学杂志》2011年第10期1239-1242,共4页China Journal of Modern Medicine

基　　金：广东省佛山市科技攻关项目(No:200808089)

摘　　要：目的评估动态血糖仪持续监测血糖联合胰岛素泵强化治疗继发性磺脲类失效(SF)患者的临床疗效,了解血糖波动和漂移的特点。方法将80例2型糖尿病SF患者随机分为治疗组及对照组(CGMS联合CSII即双C治疗组、CBG联合CSII对照组),了解血糖波动和漂移的特点。结果双C模式治疗组40例患者治疗前后的动态血糖监测自身对照全天的血糖水平均较治疗前降低,尤以餐后血糖的漂移幅度降低明显,各时段血糖均较治疗前显著降低(均P<0.001),尤以餐后3 h的血糖值下降幅度最明显。治疗组与对照组治疗前后生化指标变化无明显差异,但双C模式治疗组在CGMS连续监测下行CSII治疗比对照组能明显缩短高血糖控制时间。结论动态血糖监测能更为详细地评估SF患者全天血糖水平漂移变化的特征,为达到全面、精细地控制糖代谢紊乱提供依据,为胰岛素泵强化治疗奠定了坚实的基础。【Objective】 To assess the therapeutic effect and observe the fluctuation and excursion of blood glucose in patients with secondary sulfonylureas failure,treated by CGMG combined CSII.【Methods】 80 secondary sulfonylureas failure patients were divided into two groups,respectively measured by continuous glucose monitoring system（CGMS） and CBG,the fluctuation and excursion of blood glucose were examined before and after continue subcutaneous insulin therapy.【Results】 The glycemic excursions of test group revealed that the daily glycemic levels were lower than before treatment,there was no statistical significance in chemical index between two groups.However,significantly differences were founded between two groups the control time of blood glucose.【Conclusion】 The glycemic excursions of secondary sulfonylureas failure patients can be measured by CGMS in detail and may have beneficial effects in intensive glycemic treatment of CSII,CGMS is superior to CBG.

关 键 词：动态血糖仪监测 胰岛素泵强化治疗 继发性磺脲类失效 血糖漂移 

分 类 号：R587.2[医药卫生—内分泌]