经皮冠状动脉介入术后气虚血瘀证对抗栓疗效的影响  

Influence of Syndrome of Qi Deficiency with Blood Stasis on the Anti-thrombosis Effect after Percutaneous Coronary Intervention

作　　者：张娅[1] 陈慧[2] 李灿东[3] 吴红霞[2] 林云钗[2] 

机构地区：[1]福建中医药大学中西医结合研究院 [2]福建省立医院心内科 [3]福建中医药大学中医证研究基地

出　　处：《中医杂志》2011年第10期859-861,共3页Journal of Traditional Chinese Medicine

基　　金：卫生部科学研究基金福建省卫生教育联合攻关计划项目(WKJ2008-2-059)

摘　　要：目的探讨经皮冠状动脉介入(PCI)术后主要心血管事件(MACE)的独立危险因素。方法 123例PCI成功的冠心病患者进行术后规范抗栓治疗,同时中医辨证分为气虚血瘀组49例和非气虚血瘀组74例,7天后所有患者采血检测血小板计数(PLT)、最大血小板聚集率(MPA)、血浆遗传性假血友病因子(vWF)、血小板膜糖蛋白b/a(GPb/a)、凝血酶原片段1+2(F1+2)和纤维蛋白原(Fg),运用Logistic回归筛选出PCI术后1年MACE的独立危险因素。结果 PCI术后气虚血瘀组MPA、vWF、GPb/a高于非气虚血瘀组(P<0.05),而PLT、F1+2和Fg两组间差异无统计学意义(P>0.05)。结论 PCI术后气虚血瘀证仍存在明显的血小板活化和血管内皮损伤,是PCI术后MACE的独立危险因素之一。Objective To explore the independent risk factors for the major cardiovascular events （MCVE） after percutaneous coronary intervention （PCI）. Methods Totally 123 coronary heart disease （CHD） patients successful treated by PCI were given standard anti-thrombosis treatment,and they were classified into the qi deficiency with blood stasis group （49 cases） and non-qi deficiency with blood stasis group （74 cases） according to TCM syndrome differentiation. Seven days later,all patients were examined with blood test to observe their platelet count,maximum platelet aggregation （MPA）,plasma hereditary false hemophilia factor vWF,platelet membranous glycoprotein Ⅱ b/Ⅲ a （GPⅡ b/Ⅲ a）,prothrombin fragment 1＋2 （F1＋2）,and fibrinogen （Fg）. Using Logistic regression analysis to screen out the independent risk factors for MCVE one year after PCI. Results The MPA,vWF,and GPⅡb/Ⅲa of the qi deficiency with blood stasis group were higher than those of the non-qi deficiency with blood stasis group （P0.05）,while the platelet count,F1＋2,and Fg of the two groups were without statistical difference （P0.05）. Conclusion There still exists the obvious platelet activation and vascular endothelial injury in qi deficiency with blood stasis after PCI,. This is one of the independent risk factor for MCVE after PCI.

关 键 词：经皮冠状动脉介入术 气虚血瘀证 抗栓治疗 主要心血管事件 

分 类 号：R541.4[医药卫生—心血管疾病]