紫外分光光度法测定利培酮分散片中利培酮的含量  

Content Determination of Risperidone Dispersible Tablet by UV Spectrophotometry

作　　者：陈建征[1] 刘秀英[1] 郑世君[1] 

机构地区：[1]江苏恩华药业股份有限公司技术中心,徐州市221007

出　　处：《中国药房》2011年第20期1906-1908,共3页China Pharmacy

摘　　要：目的:建立测定利培酮分散片中利培酮含量的方法。方法:采用紫外分光光度法。溶剂为无水乙醇,在279nm波长条件下测定利培酮分散片中利培酮的含量。结果:利培酮检测浓度在6.12～30.6μg·mL-1范围内与吸光度呈良好的线性关系(r=0.9999);平均回收率为100.31%,RSD=0.54%(n=9)。结论:本法准确、可靠、重复性好,可用于利培酮分散片的质量控制。OBJECTIVE： To establish the method for the content determination of Risperidone dispersible tablet. METHODS： UV spectrophotometry was adopted using absolute alcohol as solvent. The detection wavelength was set at 279 nm. RESULTS： The linear range of risperidone was 6.12～30.6 μg·mL-1 （r=0.999 9） with an average recovery of 100.31%（RSD=0.54%, n=9）. CONCLUSION： The method is accurate, reliable and reproducible for the content determination of Risperidone dispersible tablet.

关 键 词：利培酮分散片 含量测定 紫外分光光度法 

分 类 号：R917[医药卫生—药物分析学]