蛇葡萄根的保肝降酶及抗自由基损伤作用  

Effects of the Root of Ampelopsis Sinica on Protecting Liver, Reducing Enzymes, and Resisting Free Radicle Injury

作　　者：张秀明[1] 陈科力[2] 李翰明 张赤志[2] 姚明全[3] 

机构地区：[1]湖北中医学院 [2]湖北中医学院药学系,武汉430061 [3]荆州市第一人民医院

出　　处：《中国药师》1999年第5期225-226,共2页China Pharmacist

基　　金：湖北省自然科学基金

摘　　要：用D-氨基半乳糖(D-GalN)制备大鼠急性肝损伤模型,检测血清谷丙转氨酶(ALT)、谷草转氨酶(AST)和肝匀浆超氧化物歧化酶(SOD)、丙二醛(MDA)含量,观察肝组织病理变化,以探讨中药蛇葡萄根对急性肝损害的保护作用。结果显示:蛇葡萄很能显著降低血清ALT、AST含量,提高SOD含量,降低MDA含量,高剂量组还能减轻肝细胞受损程度。提示蛇葡萄根具有保肝降酶及抗自由基损伤作用。Acute hepatic injury model of rats were induced by D-GalN. The ALT, AST in serum and SOD, MDA in liver homogenate were detected. Changes of histopathology were observed. The results showed that the extract of roots of Ampelopsis sinica could reduce serum levels of ALT, AST; raise SOD and reduce MDA in liver homogenate; promote revision of injuried liver cells to some extent. We concluded that the root the multiple roles of Ampelopsis sinica showed the multiple roles of protecting liver, reducing enzymes and resisting free radicle injury.

关 键 词：蛇葡萄 D-氨基半乳糖 肝损伤 大肠 中药 

分 类 号：R259.750.5[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]