朊病毒实验室风险评估  

LABORATORY RISK ASSESSMENT OF PRION

作　　者：宋娟[1,2] 王颖[1,2] 崔雨[1,2] 甘星[1,2] 李朝品[1] 韩俊[2] 董小平[2] 

机构地区：[1]安徽理工大学医学院病原生物学教研室,淮南232001 [2]中国疾病预防控制中心病毒病预防控制所传染病预防控制国家重点实验室

出　　处：《现代预防医学》2011年第10期1930-1932,共3页Modern Preventive Medicine

基　　金：国家自然科学基金委项目(30771914和30800975);传染病重大专项(2009ZX10004-101;2008ZX10004-001;2008ZX10004-002);卫生公益性行业(200802021)资助

摘　　要：[目的]为从事朊病毒相关操作的实验室做好有关的风险评估及生物安全防护工作提供依据。[方法]从朊病毒的病原学、致病性、传播途径、危害性、预防和实验活动的特点等方面提出朊病毒实验室风险评估要求。[结果]朊病毒实验室风险评估有利于建立朊病毒实验室标准操作程序从而有助于保护朊病毒实验人员。[结论]朊病毒的实验室风险评估是朊病毒实验室活动的前提,对保护实验室工作人员的安全具有非常重要的意义。[Objective]To provide the evidence for the risk assessment of prion laboratory[Methods]The principal hazardous characteristics of prion was analysised from etiology,transmission,pathogenicity,epidemiology,hazard and prevention.Risk of prion related operations were evaluated by its capability to infect and cause disease,its virulence by the severity of disease,and the availability of preventive measures and treatments for prion disease.[Results]Laboratory risk assessment of prion helps to establish laboratory standard operating procedure to protect staff from infection against prion.[Conclusion]Risk assessment of prion is prerequisite of selecting the appropriate practices and level of containment for prion laboratory.

关 键 词：朊病毒 实验室 风险评估 

分 类 号：R373[医药卫生—病原生物学]