美托洛尔缓释片对代谢综合征患者心率震荡的影响  

THE EFFECTS OF SUSTAINED RELEASE TABLETS OF METOPROLOL ON HEART RATE TURBULENCE IN PATIENTS WITH METABOLIC SYNDROME

作　　者：林云[1] 李天发[1] 钟江华[1] 何喜民[1] 吴月平[1] 顾申红[1] 曾春芳[1] 

机构地区：[1]海南医学院附属医院心内科,海口570102

出　　处：《现代预防医学》2011年第10期1972-1973,1975,共3页Modern Preventive Medicine

摘　　要：[目的]观察代谢综合征患者与对照组心率震荡的变化及美托洛尔缓释片对代谢综合征心率震荡的影响。[方法]①检测代谢综合征及对照组心率震荡的差别。②单纯的MS(A组)及伴有靶器官损害的MS(B组)经美托洛尔缓释片干预后,治疗前后两组心率震荡的差别。[结果]MS组与对照组间TO、TS、LVEF差异有统计学意义(P﹤0.05),MS组低于对照组,A组与B组比较,显示A组TS、LVEF较B组降低(P﹤0.05),TO无统计学意义,经美托洛尔干预治疗后,MS组治疗前后比较,结果显示前后TO、TS比较差异有统计学意义(P﹤0.05),LVEF比较差异无统计学意义(P﹥0.05)。[结论]MS存在着心率震荡的异常,尤其是伴有靶器官损害者,经过美托洛尔干预后,心率震荡明显改善,而LVEF无改变。[Objective]To observe the changes of heart rate turbulence（HRT）between metabolic syndrome（MS）group and control group,and the effects of Sustained release tablets of metoprolol on HRT in patients with MS.[Methods]① We compared differences of HRT between the MS group and the control group.②We also compared HRT after treatment with sustained release tablets of metoprolol to that before treatment in both pure MS group（A group）and target organ damage associated with MS group（B group）.[Results]TOTS and LVEF were significantly different（P﹤0.05）on TO between the MS group and the control group.Compared to those in the B group,TS and LVEF in the A group were lower（P﹤0.05）,and there were no difference between group A and group B.In the MS group,TO and TS were significantly different（P﹤0.05）after treatment with sustained release tablets of metoprolol compared with those before treatment,and there was not change for LVEF before and after treatment（P﹥0.05）.[Conclusion]There are abnormal HRT in the patients with MS,particularly in those patients associated with target organ damage.After treatment with metoprolol,HRT are significantly improved,and there is not change for LVEF.

关 键 词：心率震荡 代谢综合症 美托洛尔缓释片 

分 类 号：R589[医药卫生—内分泌]