三维适形放射治疗同步化疗联合热疗对局部晚期及术后局部复发直肠癌近期疗效的研究  

EFFECT OF THERAPY ON PATIENTS WITH RECTAL CANCER WHO RECEIVED COMBINED CHEMOTHERAPY AND THERMOTHERAPY WITH THREE-DIMENSIONAL CONFORMAL RADIATION THERAPY

作　　者：代素梅[1] 卢玉娟[1] 刘洪敏[1] 陈红[1] 张绍华[1] 王瑞林[1] 

机构地区：[1]唐山市工人医院放化疗科,唐山063000

出　　处：《现代预防医学》2011年第10期1996-1997,1999,共3页Modern Preventive Medicine

摘　　要：[目的]探讨三维适形放射治疗同步化疗联合热疗治疗局部晚期及术后复发直肠癌的临床疗效及耐受性。[方法]将45例接受同步放化疗的局部晚期及术后复发直肠癌患者随机分为两组:观察组22例、对照组23例,两组的放化疗方法一致:化疗采用卡培他滨口服1250mg/(m2.d),分为两次口服,d1～14,休息7d后重复下一治疗周期。放疗采用6MVX线照射,总剂量DT60～66Gy/1.8～2Gy/次/d,5次/周。观察组采用放化疗联合热疗,热疗每周两次,每次60min,每次间隔72h,共进行6～8次,在放疗前后1h内进行。对照组单纯采用同步放化疗。比较2组的近期疗效、疼痛缓解及毒副反应情况。[结果]观察组疼痛缓解率90.9,对照组65.2,两组疼痛缓解率比较差异有统计学意义(P﹥0.05),2组近期有效率、毒副反应差异无统计学意义(P﹥0.05)。[结论]热疗联合三维适形放射治疗同步化疗能提高局部晚期及术后复发直肠癌患者的生活质量,且不增加毒副反应,是安全有效的治疗方案。[Objective]To evaluate the efficacy of combined chemotherapy and thermotherapy with three-dimensional conformal radiation therapy（3-DCRT）for patients of rectal cancer.[Methods]45 patients with rectal cancer were randomly divided into two groups,radiochemotherapy with thermotherapy group（observed group with 22 patients）and radiochemotherapy group（control group with 23 patients）.The two groups accepted a standard chemoradiotherapy.Capecitabine was used,with a dosage of 1 250 mg/（m2.d）,and there were two treatment periods,and each period was two weeks,and the interval of the two treatment group was one week.The radiotherapy medicine was 6MVX,and the total dosage was DT 60-66Gy/1.8-2Gy/time/day,and five times a week.The observation group accepted chemoradiotherapy combined with heat therapy,and the heat therapy was two times a week,and each time had 60 minutes,and the interval was 72 hours.A total of 6-8 therapies were conducted.The control group was conducted concurrent chemoradiotherapy.We compared the current treatment effect,pain relief and adverse effects between the two groups.[Results]The effective rate of pain relief in observed group was 90.9%,and was 65.2% in control group.It showed statistically different between the two groups（P﹤0.05）.The two groups did not show significant difference in the side effects and efficiency（P﹥0.05）.[Conclusion]The efficacy of combined chemotherapy and thermotherapy with radiotherapy for rectal cancer may elevate survival quality,and the adverse effects are tolerance.

关 键 词：直肠癌 同步放化疗 热疗 

分 类 号：R453[医药卫生—治疗学] R730.55[医药卫生—临床医学]