组合药物植入剂体外释药行为研究  

Study on Release Behavior of Multi-drug Implantable Drug Delivery System

作　　者：黄卫东[1] 李胜方[1] 邹涛[1] 夏贤友[1] 刘颋[1] 

机构地区：[1]黄石理工学院化学与材料工程学院,湖北黄石435003

出　　处：《黄石理工学院学报》2011年第2期25-28,43,共5页Journal of Huangshi Institute of Technology

基　　金：湖北省教育厅科学技术研究优秀中青年资助项目(项目编号:Q20093002);黄石理工学院校级科学研究项目(项目编号:09yjz02R);黄石理工学院校级重点教学研究项目(项目编号:20090002)

摘　　要：植入式给药系统是直接在病灶部位释药的创新制剂,植入部位药物浓度高,而进入血液的药物浓度很低。制备了含多种药物的植入式给药系统,对其体外药物释放行为进行了研究,研究表明,左氟沙星更容易释放出来,而利福平释放速度比较慢,可以实现利福平先释放,然后左氟沙星开始释放;或左氟沙星先释放,然后利福平开始释放,获得2种药物分阶段释放。通过植入剂释放行为研究揭示,组合药物植入式给药系统相对传统释药方式具有给药效率高的优势。A The implantabh drug delivery system （IDDS） is a novel drug delivery forms by which the drug lib- erates directly in disease focus. The multi - drug IDDS with different kinds of structure were fabricated and their in vitro dissolution tests were investigated. The release characteristics of IDDS with simple structure il- lustrated that LVFX could be released easily from IDDS and two drugs were released from these devices dis- continuously. One was liberated after the other with the delay, which indicated multi - drug IDDS having un- ambiguous advantages over the conventional drug delivery device in terms of efficiency of drugs.

关 键 词：组合药物 植入式给药系统 释药行为 

分 类 号：Q819[生物学—生物工程]