关节滑膜内衬细胞凋亡在骨关节病发生机制中的作用  

Effects of apoptosis of synovial lining cells on pathogenesis of osteoarthropathy

作　　者：邱续强[1] 周江南[1] 

机构地区：[1]附属湘雅医院运动医学科,长沙410008

出　　处：《湖南医科大学学报》1999年第5期441-444,共4页Bulletin of Hunan Medical University

摘　　要：观察１２ 例骨关节病及１０ 例正常关节的滑膜内衬细胞的细胞凋亡情况，作定量分析且用滑膜组织的ＤＮＡ 凝胶电泳加以证实。结果示，骨关节病滑膜内衬细胞凋亡指数（２－０４ ％ ） 明显高于正常关节组（０－６０ ％ ） ；ＤＮＡ 凝胶电泳亦示病理组在２００ ｂｐ 处有明显的梯带，对照组则无。提示骨关节病滑膜内衬细胞有高于正常的转换频率，其凋亡作用增强可能在骨关节病的发生发展中有重要意义。The author counted synovial lining cells(SLCs) of apoptosis in the joints of osteoarthropathy(OA, 12 cases) and control(10 cases) patients. The counts of apoptotic SLC were investigated by gel electrophoretic analysis of DNA extracted from synovium. The apoptotic index(AI) of SLCs in OA(2.04%) was obviously higher than that in controls(0.60%); electrophorectogram of DNA revealed a characteristic ladder pattern of DNA fragments at 200?bp in the OA group. We conclude that apoptosis can be found in synovial lining layer, and the AI of SLCs in the OA group is much higher than that in the control group, implying the high turn over rate of SLCs in OA; the increasing apoptosis of SLCs may increase lesion factors retained in joints and cause the injury of articular cartilage.

关 键 词：内衬细胞 骨关节病 关节滑膜 细胞凋亡 

分 类 号：R684.02[医药卫生—骨科学]