缺血性中风急性期证候特征与生物学指标的关系  

An exploration of relationship between TCM syndrome and biomarkers for acute ischemical stroke based on GRI and C&RT algorithm

作　　者：刘璐[1] 高颖[1] 马斌[1] 

机构地区：[1]北京中医药大学东直门医院神经内科,北京100700

出　　处：《中华中医药杂志》2011年第5期1086-1090,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家科技重大专项"重大新药创制"课题(No.2009ZX09502-028);国家重点基础研究发展计划(973计划)课题(No.2003CB517102)~~

摘　　要：目的:探讨缺血性中风急性期证候与相关生物学指标的关系,从微观辨证的角度阐明证候与疾病的关系。方法:用ELISA法测定175例急性期缺血性中风病患者起病后72h内、第7、14d热休克蛋白70(HSP70)、细胞间黏附分子1(ICAM-1)及金属基质蛋白酶9(MMP9)表达水平的变化,并动态采集四诊信息判断其证候要素。应用广义规则归纳(GRI)和分类回归树(C&RT)对其数据进行挖掘分析。结果:应用GRI发现血瘀证在3个时间点均与缺血性中风急性期相关生物学指标存在密切关联。应用C&RT发现HSP70表达水平是影响气虚证最重要的因素。结论:研究提示HSP70、ICAM-1、MMP9可能是缺血性中风急性期血瘀证的微观指标,提示HSP70可能为气虚证的微观指标。Objective：To explore relationship between TCM syndrome and biomarkers for acute ischemical stroke.Methods：Serum samples from 175 patients after the onset of 72 hours,7days and 14 days were tested by ELISA in order to detect the expression of HSP70,ICAM-1 and MMP9.Dynamic clinical data were collected aiming to determine TCM Syndrome Factors.Decision Tree Learners（CRT） and a method for mining association rules（GRI algorithm） were used.Results：GRI algorithm：A list of association rules between Blood stasis syndrome and biomarkers after the onset of 72 hours,7days and14 days was obtained.CRT algorithm：HSP70 was main factor that affected qi deficiency syndrome.Conclusion：These results indicated that HSP70,ICAM-1,MMP9 might be microscopic indices of Blood stasis syndrome and HSP70 might be microscopic index of qi deficiency syndrome for acute ischemic stroke

关 键 词：缺血性中风 证候要素 生物学指标 广义规则归纳 分类回归树 

分 类 号：R277.7[医药卫生—中医学]