人参皂苷Rg1对BALB/c小鼠免疫调节作用的实验研究  

Immunological regulation of ginsenoside Rg1 in ovalbumin-immunized BALB/c mice

作　　者：周英武[1] 彭桂英[1] 葛东宇[1] 邱泽计[1] 顾立刚[1] 

机构地区：[1]北京中医药大学中医药防治病毒性疾病教育部重点实验室,北京100029

出　　处：《中华中医药杂志》2011年第5期1232-1234,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金青年科学基金资助项目(No.30701105)~~

摘　　要：目的:研究人参皂苷Rg1对BALB/c小鼠免疫调节作用的影响。方法:采用6-8周雌性BALB/c小鼠共30只随机分成6组,分别是生理盐水(normal saline,NS)组、人参皂甙Rg1组、铝盐(aluminum hydroxide,Al)组、卵清白蛋白(ovalbumin,OVA)组、OVA+Al组和OVA+Rg1组,每组5只。颈部皮下接种,免疫3次。结果:OVA+Rg1组与OVA组相比,总IgG、IgG1、IgG2a、IgG2b和γ-干扰素(interferon-γ,IFN-γ)分泌水平增高,淋巴细胞增殖能力增强(P<0.05)。结论:人参皂甙Rg1引起混合性Th1/Th2平衡免疫反应细胞,从而增强小鼠对卵清蛋白的特异性免疫应答。Objective：Immunological regulation of ginsenoside Rg1 in ovalbumin（OVA）-immunized mice was investigated.Methods：30 six to eight weeks BALB/c female mice were divided into six groups：normal saline group（NS group）,Rg1 group,aluminum hydroxide group（AL group）,ovalbumin group（OVA group）,OVA＋Al group,OVA＋Rg1 group.The mice were subcutaneously inoculated three times with OVA alone or in combination with Rg1 or aluminum hydroxide（Alum） for three times.Results：Significantly higher levels of specific total IgG,IgG1,IgG2a and IgG2b subclass responses as well as IFN-γ secretion and lymphocyte proliferation responses（P〈0.05） were induced in mice immunized with OVA plus Rg1,in contrast with the control（immunized with OVA only）.Conclusion：Rg1 had evoked a mixed Th1/Th2 balance immune response,and enhanced the specific immune responses in mice immunized with ovalbumin.

关 键 词：人参皂甙RG1 免疫调节作用 实验研究 

分 类 号：R285.5[医药卫生—中药学]