尿激酶型纤溶酶原激活物和p38促丝裂原激活蛋白激酶信号通路与头颈肿瘤侵袭  

Urokinase-type plasminogen activator and p38 mitogen-activated protein kinase signaling pathway in the invasion of head and neck tumor

作　　者：钟旖[1] 王丽[1] 陈新明[1] 

机构地区：[1]武汉大学口腔医院病理科,武汉430079

出　　处：《国际口腔医学杂志》2011年第3期367-369,共3页International Journal of Stomatology

摘　　要：细胞外基质降解是肿瘤侵袭的前提,尿激酶型纤溶酶原激活物(uPA)在其降解过程中发挥着重要的作用,p38促丝裂原激活蛋白激酶(MAPK)信号通路可通过对uPA的调节参与肿瘤的侵袭。本文就uPA和p38MAPK信号通路在头颈肿瘤的发生和侵袭中的作用作一综述。The degradation of extracellular matrix is an important prerequisite in tumor oncogenesis and invasion. Studies have shown that urokinase-type plasminogen activator（uPA） plays an important role in the degradation of extracellular matrix.It has been suggested that p38 mitogen-activated protein kinase（MAPK） signaling pathway can be involved in tumor invasion by regulating uPA expression.In this article,the research of p38MAPK-signaling pathway and uPA in the invasion of head and neck tumor are reviewed.

关 键 词：头颈肿瘤 尿激酶型纤溶酶原激活物 p38促丝裂原激活蛋白激酶信号通路 

分 类 号：R739.91[医药卫生—肿瘤]