替米沙坦与贝那普利降压及逆转左室肥厚的疗效观察  

Clinical Effects of Telmisartan and Benazepril on Hypertension and Reversing Left Ventricular Hypertrophy

作　　者：章美华[1] 孙召金[1] 

机构地区：[1]安徽医科大学附属六安医院心内科,安徽六安237005

出　　处：《河北医学》2011年第5期589-592,共4页Hebei Medicine

摘　　要：目的:分析替米沙坦与贝那普利治疗轻中度高血压的疗效和对左心室肥厚及心功能的影响。方法:将轻中度高血压病人115例随机分为替米沙坦组和贝那普利组,在服药前和服药后4周、12个月测血压,服药前和服药后12个月测量左室舒张末内径(LVD)、左室舒张期室间隔厚度(IVST)、左室后壁厚度(LVPWT)、左室射血分数(LVEF)、左室短轴缩短率(FS)、二尖瓣口舒张早、晚期血流峰值速度E/A比值。结果:服药4周后两组血压均明显下降(P<0.05),替米沙坦组稍优于贝那普利组,但两组间比较差异无显著性,两药对心率均无影响。治疗12个月后两组LVEF、FS有所升高,但差异无显著性,LVD、IVST、LVPWT及左室重量指数(LVM I)均明显降低(P<0.01),E/A比值明显升高(P<0.05)。结论:替米沙坦、贝那普利不仅能降低血压,还能明显减轻左室肥厚,改善左室舒张功能。Objective：To investigate the effects of telmisartan and benazepril on hypertension and reversing left ventricular hypertrophy,cardiac function through contrast analysis.Method：115 cases of hypertension in the stage 1-2 range were randomly divided into telmisartan group and benazepril group.Blood pressures were measured before taking drug,4 weeks and 12 months after taking drug.Left ventricular end diastolic diameter（LVEDD）,Interventricular septum thickness diastolic（IVSTd）,left ventricular posterior wall thickness（LVPWt）,Left ventricular ejection（LVEF）,Fraction shortening（FS）,E/A were measured with Doppler echocardiography before have druges,12 months after have druges.Result：Blood pressures of two groups were significantly decreased（P〈0.05）,blood pressures of telmisartan group dropped more than the group of benazepril,But there was no significant difference（P〉0.05） between two groups,and two drugs had no effect on heart ratio.LVEF and FS of two groups were significantly improved after 12 months,without significant difference（P〉0.05）.IVSTd,LVEDD,LVPWt and left ventricular mass index（LVMI） dropped significantly（P〈0.01）,and E/A improved significantly（P〈0.05）after 12 months.Conclusion：Telmisartan and benazepril could not only reduce blood pressure but also abate left ventricular hypertrophy significantly and regulate left ventricular diastolic function

关 键 词：替米沙坦 贝那普利 高血压 左心室肥厚 

分 类 号：R541.3[医药卫生—心血管疾病]