枸杞多糖促排铅功效初步研究  

Study on the role of lycium barbarum polysaccharides for eliminating lead-exposed mice

作　　者：宁红梅[1] 葛亚明[1] 雒海潮[1] 杨帆[2] 

机构地区：[1]河南科技学院动物科学学院,河南新乡453003 [2]新乡医学院基础医学院,河南新乡453003

出　　处：《郑州轻工业学院学报（自然科学版）》2011年第2期9-11,共3页Journal of Zhengzhou University of Light Industry:Natural Science

基　　金：河南省教育厅科技攻关项目(2010B230003)

摘　　要：选用48只昆明小鼠随机分为6组:正常对照组;铅中毒模型对照组;EDTA对照组;枸杞多糖低、中、高剂量组.进行为期30 d的不同喂食试验,测定小鼠的血铅及股骨和肝脏中的铅含量与抗氧化能力.结果表明,染铅小鼠给予枸杞多糖后,可以明显降低血铅和股骨、肝脏中铅含量(p<0.05),提高超氧化物歧化酶活性(p<0.05).枸杞多糖具有明显的促排铅效果.48 Kunming mice were divided into 6 groups for control group,lead model group,EDTA group,low,medium,and high lycium barbarum polysaccharides（LBP） doses groups.The lead concentrations in blood,liver and femur and the activity of SOD in serum were detected at the 30th day.The results showed that the levels of blood lead,liver lead and femur lead were significantly decreased in poisoning mice exposed to LBP（p〈0.05）.At the same time,the activity of SOD was increased remarkably in LBP groups.LBP has a remarkable effect of lead-eliminating from lead-exposed rats.

关 键 词：枸杞多糖 铅中毒 排铅 

分 类 号：R995[医药卫生—毒理学]