用于检测小分子靶标的电流型识体传感器研究进展  

Current development of aptamer-based amperometric sensors for the determination of small molecule targets

作　　者：姜利英[1] 陈青华[1] 王云龙 崔光照[1] 

机构地区：[1]郑州轻工业学院电气信息工程学院,河南郑州450002 [2]河南生物工程技术研究中心,河南郑州450001

出　　处：《郑州轻工业学院学报（自然科学版）》2011年第2期56-59,共4页Journal of Zhengzhou University of Light Industry:Natural Science

基　　金：国家自然科学基金项目(61002007)

摘　　要：综述了电流型识体传感器在检测小分子靶标方面的研究进展:通过目标分子与电极上固定的核酸识体结合引起电流或电阻的变化和通过改变电活性物质与电极之间的距离2种方法均可检测目标靶分子.指出提高电流型识体传感器的灵敏度和适用性将是未来的发展方向.The current development of the aptamer-based amperometric sensor for the determination of small molecule targets was reviewed.The targets were detected according to electrical current or resistance changes caused by the binding of target with the aptamer immobilizated onto the electrode surface and distance changes between the electroactive molecule and electrode,based on the principle of aptamer-based amparometric sensor.To improve the sensitivity and selectivity will be the future development direction of the aptamer-based amperometric sensor.

关 键 词：核酸识体 小分子靶标 电流型传感器 

分 类 号：Q7[生物学—分子生物学]