益气活血解毒法对溃疡性结肠炎结肠组织多药耐药性的影响  

Influence of Increasing Pneuma to Promoting Blood Flow and Deintoxication Method on Multidrug Resistance in Colon Tissue of Ulcerative Colitis

作　　者：安贺军[1] 王新月[2] 于玫[3] 沈静[3] 

机构地区：[1]中国人民解放军第306医院,北京100101 [2]北京中医药大学东直门医院,北京100700 [3]北京中医药大学,北京100029

出　　处：《中医学报》2011年第4期439-441,共3页Acta Chinese Medicine

基　　金：国家自然科学基金资助项目(编号:30572390)

摘　　要：目的:探讨益气活血解毒法对溃疡性结肠炎(UC)结肠组织多药耐药性的影响。方法:分临床及动物实验两部分,临床选择90例UC复发患者治疗90 d后对完全缓解及有效病例(其中治疗组39例,对照组32例)进行为期0.5 a的随访。治疗组给予益气活血解毒立法的中药汤剂,对照组给予柳氮磺胺吡啶治疗,并与20例作正常对照。动物实验用三硝基苯磺酸(TNBS)复制实验性大鼠UC模型,随机分为模型组、抗溃结复发方组、畅美组,并设正常对照组。结果:临床研究治疗前UC组结肠组织P-糖蛋白水平明显高于正常健康人(P<0.01);复发组水平明显高于未复发组(P<0.01);治疗组治疗后及随访时结肠组织P-糖蛋白水平明显低于对照组(P<0.01)。动物实验在治疗10d和治疗30 d时,两组之间相比无显著差异(P>0.05);停药10 d时,畅美组水平明显高于抗溃结复发方组(P<0.01)。结论:以益气活血解毒为主的中药汤剂与西药比较,有效地抑制了P-糖蛋白的表达,从而发挥拮抗多药耐药的作用。Objective：To investigate increasing pneuma for promoting blood flow and deintoxication method on muhidrug resistance in colon tissue of ulcerative colitis. Methods：h is divided into clinic and animal experiment parts. In clinical experiment,90 cases with UC recurrence were randomly divided into the treatment group （n = 39 ） and the control group （n = 32） according to the random table. After 3 months＇ treatment, the cases of complete remission and utility were given follow - up visits （ treatment group, n = 39 ; control group, n = 32）. The patients of treatment group accepted medicinal broth of increasing pneuma for promoting blood flow and deintoxication treatment;the control group were given Salazosulfapyridine. In animal experiment part, UC model of experimental rats were duplicated with TNBS and randomly divided into model control group, anti -ulcer and anti -recurrent group, olsalazine sodium capsule group and normal control group. Results：In clinical part, there were obvious differences between treatment group and control group. Before treatment, the level of colon tissue multidrug resistance in UC group was higher than that in healthy people （ P 〈 0.01 ） ; the level of recurrence group was higher than that in non - recurrence group （ P 〈 0.01 ） ; but after treatment and follow - up visits, the level of colon tissue in treatment group was much lower than that of the control group（ P 〈 0.01 ）. In animal experiment part, after treating for 10 days and 30 days, two groups have no significant difference （ P 〉 0.05 ）. In discontinuation of 10 days, the level of rats of the olsalazine sodium capsule group was markedly higher than that of the anti - ulcer and anti - recurrent group（ P 〈 0.01 ）. Conclusion：The study shows medicinal broth of increasing pneuma for promoting blood flow and deintoxication treatment could cut down the level of colon tissue multidrug resistance than treatment with western medicine. Accordingly the drug resistance is restrained.

关 键 词：结肠炎 益气活血解毒法 P-糖蛋白 

分 类 号：R266[医药卫生—中医外科学]