黄连解毒汤不同剂型抗菌药效实验研究  

Study on the Antibacterial Effect of Huang-Lian-Jie-Du-Tang in Different Dosage-forms

作　　者：罗海燕[1] 邝枣园[1] 李岩[1] 黄暨生[1] 黄少伟[1] 李明[2] 

机构地区：[1]广州中医药大学基础医学院,广东广州510006 [2]广东药学院基础学院,广东广州510006

出　　处：《临床医学工程》2011年第5期647-648,共2页Clinical Medicine & Engineering

基　　金：广东省自然科学基金(编号:10151022401000000);广东省医学科研基金(编号:A2008316)

摘　　要：目的从体外抗菌效果的角度比较黄连解毒汤颗粒剂和黄连解毒汤煎剂两种剂型的药效。方法用试管内药液两倍稀释法分别测定黄连解毒汤颗粒剂和黄连解毒汤煎剂对不同细菌的最小抑菌浓度(MIC)。结果两种剂型对各实验菌的MIC分别为:黄连解毒汤颗粒剂介于0.0020～0.5000g·ml-1;黄连解毒汤煎剂对大肠埃希氏菌不敏感(>0.50g·ml-1),对其余实验菌介于0.0078～0.1250g·ml-1。结论黄连解毒汤颗粒剂的抑菌作用优于黄连解毒汤煎剂,可以作为黄连解毒汤煎剂的替代品。Objective To compare the different antibacterial effects of Huang-Lian-Jie-Du-Tang in different dosage-forms.Methods The minimal inhibitory concentration（MIC） of Huang-Lian-Jie-Du-Tang in different dosage-forms to different kinds of bacterium was detected by tube dilution method.Results MIC of Huang-Lian-Jie-Du-Tang granule was from 0.0020 to 0.5000 g·ml-1,MIC of Huang-Lian-Jie-Du-Tang decoction was from 0.0078 to 0.1250 g·ml-1.Conclusion Judging from the results,the antibacterial effect of granule is better than decoction.Therefore,Huang-Lian-Jie-Du-Tang granule should be a alternative to Huang-Lian-Jie-Du-Tang decoction.

关 键 词：黄连解毒汤 颗粒剂 煎剂 最小抑菌浓度 

分 类 号：R283.6[医药卫生—中药学]