β内酰胺酶分子流行病学研究进展  

Research Progress on Molecular Epidemiology of β-lactamases

作　　者：郭丽双[1] 胡静[1] 冯玉宽[1] 

机构地区：[1]牡丹江医学院,黑龙江牡丹江157011

出　　处：《医学综述》2011年第9期1309-1311,共3页Medical Recapitulate

摘　　要：革兰阴性杆菌产β内酰胺酶(BLA)是对β内酰胺类抗生素耐药的主要机制。近年来,随着抗生素的大量使用,细菌等微生物对药物产生了适应性进化,BLA新的类型及基因的新型别不断出现。了解细菌产BLA类型,对临床合理使用抗生素有理论指导意义。在此在介绍BLA分类、作用机制及作用场所等研究的基础上,对重要的BLA类型、各型的主要基因型别及其流行情况予以简要综述。The primary mechanism responsible for β-lactam antibiotic-resistance in Gram-negative bacilli（BLA） is the production of β-lactamase.With the wide use of antibiotics,an adaptive evolution of microorganism including bacteria keep appears in response to antibiotics.A large number of new drug-re-sistant genes are emerging continuously.The understanding of β-lactamases produced by bacteria plays an important instrumental role in the rational application of antibiotics.This article briefly reviews BLA classification,mechanisms of action,and site of action,especially major BLA types,key genotypes and epidemiology.

关 键 词：Β-内酰胺酶 基因类型 流行 

分 类 号：R278.99[医药卫生—中医学]