乳果糖联合培菲康对肝硬化自发性腹膜炎血清和腹水TNF-α、IL-6水平的影响  

The effects of lactulose and bifid lriple viable on the levels of TNF-α and interleukin-6 levels in serum and ascites in cirrhosis patients with spontaneous bacterial peritonitis

作　　者：储建坤[1] 刘荣欣[1] 张征[1] 杨涛[1] 陈慧巧[2] 

机构地区：[1]河北医科大学第一医院消化内科,石家庄市050031 [2]河北省石家庄市第二医院门诊部

出　　处：《河北医药》2011年第10期1451-1452,共2页Hebei Medical Journal

摘　　要：目的探讨乳果糖联合培菲康对肝硬化自发性细菌性腹膜炎血清及腹水TNF-α、IL-6水平的影响。方法选择自发性细菌性腹膜炎患者120例,随机分为对照组(n=60)和治疗组(n=60),另外选择健康体检者30例为健康对照组。所有患者均于治疗前、治疗后7 d测定血清及腹水TNF-α、IL-6水平,并统计患者的病死率。结果治疗组和对照组患者血清及腹水TNF-α、IL-6水平显著高于健康对照组(P<0.05);治疗后相比,治疗组血清及腹水TNF-α、IL-6水平较对照组明显下降(P<0.05);治疗组的病死率明显低于对照组。结论乳果糖联合培菲康可以降低肝硬化自发性腹膜炎患者血清及腹水TNF-α、IL-6水平,改善患者预后。Objective To observe the effects of lactulose and bifid lriple viable on the levels of TNF-α and interleukin-6（IL-6） in serum and ascites in cirrhosis patients with spontaneous bacterial peritonitis（SBP）.Methods 120 cirrhosis patients with SBP were randomly divided into two groups： treament group（n=60） and control group（n=60）,and 30 healthy subjects were served as healthy control group.All the cases were observed for 7 days.The concentrations of TNF-α and IL-6 in patients＇ serum and ascites were detected before and after 7-day treatment with lactulose and bifid lriple viable,and the patients＇ mortality rate was counted.Results The levels of TNF-α and IL-6 in serum and ascites in treatment group and control group were significantly higher than those in healthy control group（P0.05）.After 7-day treatment,the levels of TNF-α and IL-6 in serum and ascites in treatment group were significantly lower than those in control group（P0.05）.The mortality rate in treatment group was significantly lower than that of control group.Conclusion The lactulose combined with bifid lriple viable can decrease the levels of TNF-α and IL-6 in serum and ascites in cirrhosis patients with SBP and can improve the patients＇ prognosis.

关 键 词：乳果糖 双歧杆菌 肝硬化 自发性腹膜炎 细胞因子 

分 类 号：R656.41[医药卫生—外科学]