顶空气相色谱法测定盐酸头孢替安中三乙胺残留量  被引量:9

Determination of Residual Organic Solvents in Cefotiam Hydrochloride by Headspace Gas Chromatography

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作  者:郭瑞[1] 王惠群[1] 杨春巧 刘建辉[1] 

机构地区:[1]石药集团中润制药,河北石家庄050041

出  处:《河北化工》2011年第5期38-39,57,共3页Hebei Chemical Industry

摘  要:建立盐酸头孢替安原料药中三乙胺残留量的测定方法。采用顶空进样毛细管气相色谱法,用DB-624毛细管柱分离,以氮气为载气,FID检测器测定三乙胺残留量。结果表明,质量浓度在考察范围内与峰面积具有良好的线性关系(r>0.999),平均回收率为97%~102%,精密度RSD均<10%,最低检出限为0.128μg/mL。该法快速、灵敏、准确,可用于盐酸头孢替安中三乙胺残留量的测定。To establish a method for determination of residual triethylamine in cefotiam hydrochloride.It was quantitatively determined by headspace gas chromatography(GC) on DB-624 column with FID detector,nitrogen as the carries.Results showed that there was a good linearity in the experimental concentration(r0.999).The RSD of precision was less than 10%.The average recovery rate ranged from 97% to 102%.The detection limits was 0.128 μg/mL.The method appears to be rapid,sensitive and accurate.It can be used for determining the content of residual triethylamine in cefotiam hydrochloride.

关 键 词:顶空气相色谱法 盐酸头孢替安 三乙胺残留量 

分 类 号:O657.71[理学—分析化学]

 

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