腰椎间盘突出症的病理分型和全身及局部体液免疫水平的相关性研究  

A STUDY ON THE RELATIONSHIP BETWEEN THE PATHOLOGICAL CLASSIFICATIONS OF LUMBAR DISC HERNIATION AND LOCAL & GENERAL HUMORAL IMMUNE STATUS

作　　者：李军 刘淼 朱丽萍 

机构地区：[1]第一临床医学院骨科,西安710061

出　　处：《西安医科大学学报》1999年第3期374-377,共4页Journal of Xi'an Medical University(Chinese)

摘　　要：为探讨腰椎间盘突出症的不同病理分型和自身体液免疫状态之间的相互关系，采用速率散色比浊法和免疫组化法对２８ 例腰椎间盘突出症患者血清、脑脊液和髓核组织中ＩｇＧ、ＩｇＭ 进行测定。结果表明：①脑脊液中ＩｇＧ、ＩｇＭ 含量增高对腰椎间盘突出症有一定诊断价值；②外周血中ＩｇＧ、ＩｇＭ 的增高有助于区分腰椎间盘突出症的破裂型和游离型，可明确经皮髓核摘除术中的禁忌症；③突出的髓核组织中有免疫球蛋白沉积，可引起自身免疫反应性炎症，这是腰椎间盘退变。In order to explore relationship between pathological classifications and humoral auto immune status, the serum,cerebrospinal fluid and nucleus pulposus of 28 disc herniation patients were examined for the production of IgG and IgM by rate nephelometry and immunohistochemical protocol.The results showed:①The concentrations of IgG and IgM in CSF was helpful to diagnose the lumbar disc herniation;②The concentrations of IgG and IgM in serum were useful to distinguish extrusion and sequestration and understand the contraindication of percutaneous discectomy;③Immunoglobulin deposits could lead to a chronic inflammatory response, which caused lumbar disc degeneration,prolapse, lumbago and sciatica.

关 键 词：椎间盘突出 腰椎 病理分型 免疫水平 

分 类 号：R681.530.2[医药卫生—骨科学]