体外循环对循环巨核细胞和血小板的影响及意义  

Cardiopulmonary Bypass's Influence on Megakaryocytes and Platelet in Circulation

作　　者：赵初环[1] 林洁[2] 钱红兰[3] 冯霞飞[1] 张翔[4] 孙成超[4] 

机构地区：[1]温州医学院附属第一医院心脏监护室,浙江温州325000 [2]温州医学院附属第一医院呼吸内科,浙江温州325027 [3]温州医学院附属第一医院血液内科,浙江温州325000 [4]温州医学院附属第一医院心胸外科,浙江温州325000

出　　处：《中国现代医生》2011年第15期144-145,151,共3页China Modern Doctor

基　　金：浙江省温州市科技计划项目;项目编号:Y20080152

摘　　要：目的探讨体外循环(CPB)对循环巨核细胞和血小板的影响及意义。方法观察测定20例患者体外循环(CPB)前后巨核细胞、血小板计数(PLT)值变化,探讨体外循环(CPB)对循环巨核细胞和血小板的影响及意义。结果手术前、中、后中心静脉血的巨核细胞和4-型巨核细胞数量总数量高于同期周围动脉血的细胞总数量。体外循环中中心静脉血巨核细胞和4-型巨核细胞数量比术前和术后均升高,体外循环中血小板数量比术前和术后均降低(P<0.01)。结论体外循环可以导致巨核细胞和血小板数量的改变,循环巨核细胞可能在肺中被破坏、损耗;急性肺损伤可能影响血小板数量。Objective To explore cardiopulmonary bypass＇ s influence on platelet and megakaryocytes. Methods Megakaryocytes and platelet count （ PLT ） in 20 patients before and after eardiopulmonary bypass （ CPB ） were measured. To explore cardiopulmonary bypass＇ s influence on platelet and megakaryocytes. Results The total number of megakaryocytes and 4-type of megakaryocytes in venous blood were higher than the same arterial blood. The total number of megakaryocytes and 4--type of megakaryocytes in venous blood within CPB were higher than before and after CPB. PLT within CPB were lower than before and after CPB （ P〈0.01 ） . Conclusion CPB can lead to changes of platelet count and megakaryocytes. Platelets and megakaryocytes were destructed in lung by CPB. Injury in acute lung may affect the quantity of platelet.

关 键 词：体外循环 巨核细胞 血小板 

分 类 号：R446.1[医药卫生—诊断学]