Expression of the chemoresistance-related proteins and p53 gene as a predictor of chemotherapy response and a prognostic factor in patients with ovarian cancer at the stages of II-IV  

作　　者：MA Jia-jia CHEN Bi-liang XIN Xiao-yan 

机构地区：[1]Department of Obstetric and Gynecology, Xijing Hospital, Fourth Military Medical University, Xi＇an 710033, China

出　　处：《Journal of Life Sciences》2008年第5期10-17,共8页生命科学（英文版）

摘　　要：Objective To clarify the prognostic significance of histologic subtype and its correlation to expression of chemoresistance-related proteins （CRPs） in ovarian cancer. Methods A total of 107 stage II-IV ovarian cancers, where the proportion of serous, endometrioid, mucinous, and clear cell subtype was 62.6%, 15.9%, 14.0%, and 7.5%, respectively, were investigated for glutathione Stransferase-pi （GST-pi）, MDR （multidrug resistance）-l, and p53 expression using immunohistochemistry. Results GST-pi expression was detected in 62.6% of the tumors and was not related to histologic subtype of tumor. MDR-1 expression was observed in 52.3% of the tumors tested and was more frequently detected in serous adenocarcinomas than other histologic subtypes of tumor （P〈0.001）. P53 expression was found in 43.3% of serous, 35.3% of endometrioid, 40.0% of mucinous adenocarcinomas and 37.5% of clear cell adenocarcinomas. In univariate analysis, there are direct correlations between CRPs and overall survival. In multivariate analysis, GST-pi expression （P=0.0052）, MDR-1 expression （P=0.0058）, histologic subtype （P=0.0067）, FIGO stage （P=0.0089）, and residual tumor （P=0.0041） were found to be significant independent prognostic factors. Conclusion Histologic subtype proved to be the significant independent prognostic factor in addition to FlGO stage and residual tumor in stage II-IV ovarian cancer. GST-pi, MDR-1, and p53 expression pattern is closely related to histologic subtype of ovarian cancer, at the same time they are the significant predictors of survival.

关 键 词：chemoresistance-related protein GST-PI MDR-1 ovarian cancer p53 

分 类 号：Q2[生物学—细胞生物学] Q51