中药复光颗粒对家兔视神经夹伤后Bcl-2和Bax表达的影响  

Effect of fuguang pellet on Bcl-2 and Bax expression after optic nerve crush in rabbits

作　　者：朱劲 江文 黄玲 张晓 周华祥[2] 张燕[3] 

机构地区：[1]核工业416医院眼科,中国四川省成都市610041 [2]成都中医药大学附属医院眼科,中国四川省成都市610041 [3]四川省妇幼保健院,中国四川省成都市610041

出　　处：《国际眼科杂志》2011年第5期792-794,共3页International Eye Science

摘　　要：目的:观察复光颗粒对家兔受损视神经的保护作用。方法:采用视神经夹伤方法,建立家兔外伤性视神经病变(traumatic optic neuropathy,TON)模型,通过测定凋亡相关基因Bcl-2和Bax的表达,观察复光颗粒对受损视神经的影响。结果:视神经夹伤后,凋亡相关基因Bcl-2和Bax的表达及Bcl-2/Bax值在复光颗粒组间(低、高剂量组)比较无显著差异性(P>0.05)。而复光颗粒各组与模型对照组间均有显著差异(P<0.05),复光颗粒各组较模型组Bcl-2表达增加,Bax表达减少。结论:在本实验条件下,复光颗粒具有上调抗凋亡基因Bcl-2和下调促凋亡基因Bax表达的作用,可减轻视神经损伤的作用。·AIM：To observe the protective effect of fuguang pellet on optic nerve through the research of expression of apoptosis-related genes（Bcl-2,Bax）in the rabbits after crushing the optic nerve with microforceps.·METHODS：By the method of crushing rabbit optic nerve,the models of traumatic optic neuropathy（TON）were set up.By determination of the expression of apoptosis-related genes（Bcl-2,Bax）in the rabbits＇ optic nerve,the influence of the fuguang pellet on injured optic nerve was observed.·RESULTS：After the rabbits＇ optic nerve was crushed,there were significant differences in the expression of apoptosis-related genes（Bcl-2,Bax）between model group and the group of the fuguang pellet（P0.05）.There were no significant differences between the group of high-dosage group and low-dosage group of the fuguang pellet.·CONCLUSION：Fuguang pellet can decrease damages of optic nerve by increasing Bcl-2 gene expression and restraining Bax gene expression in this experiment.·

关 键 词：视神经夹伤 家兔 BAX BCL-2 凋亡基因 外伤性视神经病变 

分 类 号：R285.5[医药卫生—中药学]