8-异构前列腺素F2α和超敏C反应蛋白与冠心病的相关性研究  

Clinical study of correlation between 8-Iosmerie porastglnadin-2a （8-iso-PGF2α）, hypersensitive C-reactive protein（hs-CRP）and coronary heart disease（CHD）

作　　者：包忠武[1] 申强[1] 蒋军军[1] 艾庆[1] 周俊[1] 舒易文[1] 朱永芝[1] 

机构地区：[1]南华大学附属怀化医院,怀化市第一人民医院心内科,湖南省怀化418000

出　　处：《中国基层医药》2011年第5期588-590,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 探讨8-异构前列腺素F2α（8-iso-PGF2α）和超敏C-反应蛋白（hs-CRP）的血清水平在监测冠心病病情方面的作用及与冠状动脉病变程度的关系.方法 冠心病患者153例,按临床诊断分为急性心肌梗死（AMI）组52例、不稳定型心绞痛（UAP）组50例、稳定型心绞痛（SAP）组51例;对照组50例.测定各组hs-CRP、8-iso-PGF2α的水平.结果 AMI组、UAP组及SAP组的8-iso-PGF2α（mg/L）分别为（524.12±0.67）、（327.24±0.78）、（127.38±1.29）;hs-CRP（mg/L）分别为（18.16±0.77）、（13.76±1.13）、（7.64±0.98）;均比对照组高（均P＜0.05）;AMI组、UAP组和SAP组8-iso-PGF2α和hs-CRp水平相比,差异均有统计学意义（均P＜0.05）;8-iso-PGF2α和hs-CRp水平变化呈正相关.结论 血清8-iso-PGF2α和hs-CRP可能是冠状动脉粥样硬化的标志,参与了冠心病的发病过程,其水平与冠状动脉病变程度密切相关.Objective To study the correlation between 8-Iosmerie Porastglnadin-2a（8-iso-PGF2α） 、hypersensitive C-reactive protein（hs-CRP） and coronary heart disease（CHD）. Methods 153 CHD patients were divided into 3 groups,including 52 cases of acute myocardial infarction（AMI） ,50 cases of unstable angina（UAP） ,51 cases of stable angina（SAP） and control group consisted of 50 healthy people. The levels of hs-CRP and 8-iso-PGF2α were measured. Person correlation analysis was used to analyze the relationship between the level of hs-CRP and 8-isoPGF2α. Results The levels of hs-CRP and 8-iso-PGF2α were significantly higher in AMI, UAP and SAP group than those in control group（all P ＜0.05）. Compared with SAP group,the levels of hs-CRP and 8-iso-PGF2α were increased in AMI and UAP groups （all P ＜ 0. 05） . The level of hs-CRP was positively associated with the level of 8-iso-PGF2α. Conclusion hs-CRP and 8-iso-PGF2α should be the markers of coronary atherosclerosis and involved in the process of CHD. The levels of serum hs-CRP and 8-iso-PGF2α were correlated with the severity of CHD.

关 键 词：地诺前列素 C反应蛋白质 冠状动脉疾病 

分 类 号：R541[医药卫生—心血管疾病]