不同剂量胰岛素治疗小儿糖尿病酮症酸中毒的效果比较  

The comparison of the effects of different doses of insulin in diabetic ketoacidosis in children

作　　者：郭晓辉[1] 孙艳峰[2] 郭洪平[3] 张莹莹[1] 韩淑贞[1] 

机构地区：[1]滨州市人民医院儿科,山东省滨州256600 [2]滨州市人民医院肿瘤科,山东省滨州256600 [3]滨州市人民医院体检中心,山东省滨州256600

出　　处：《中国基层医药》2011年第5期618-619,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 探讨不同剂量胰岛素对小儿糖尿病酮症酸中毒的治疗效果.方法 选取采用胰岛素进行治疗的44例小儿糖尿病酮症酸中毒患者为研究对象,将其随机分为小剂量组22例（静脉注射胰岛素1～2 U/kg体重）和大剂量组22例（静脉注射和皮下注射胰岛素各1～2 U/kg体重）,后将两组患者的血糖、钠、钾、酸中毒纠正时间及血清IL-6、IL-12、IL-18及TNF-α水平和低血糖发生率进行比较.结果 治疗后两组患者血糖、钠、钾及血清IL-6、IL-12、IL-18、酸中毒纠正时间及TNF-α水平比较,均差异无统计学意义（均P＞0.05）,而大剂量组低血糖发生率（13.6%）却高于小剂量组（P＜0.05）.结论 在小儿糖尿病酮症酸中毒的治疗中采用小剂量胰岛素进行治疗效果较好,且血糖平稳降低.Objective To study the effects of different doses of insulin in diabetic ketoacidosisin children.Methods 44 patients with diabetic ketoacidosis in children who were treated with insulin in our hospital were selected as research object,and they were divided into group A（low dose group）22 cases and group B（high dose group）22 cases, and the blood glucose, blood calcium, serum potassium, acidosis corrected time and the levels of serum IL-6,IL-12,IL-18 and TNF-α and incidence of hypoglycemia of the two groups were compared and studied. Results The blood glucose, blood calcium,serum potassium, acidosis corrected time and the levels of serum IL-6, IL-12, IL-18 and TNF-α of the two groups had no differences, there were no significant difference（all P ＞ 0. 05）, but the incidence of hypoglycemia of the group B was lower than that of group A,there was significant difference（P ＜0. 05）. Conclusion The effects of low dose of insulin in diabetic ketoacidosis in children was better, blood glucose placidity decreases, and was worthy of further studying and popularization and application.

关 键 词：胰岛素 糖尿病酮症酸中毒 儿童 

分 类 号：R72[医药卫生—儿科]