甲基丙烯酸甲酯对雄性小鼠生殖系统的毒性  

Toxic Effect of MMA to The Reproductive System of Male Rats

作　　者：王春华[1] 陈曦[1] 曹树义[1] 

机构地区：[1]天津医科大学公共卫生学院劳动卫生学教研室,300070

出　　处：《职业与健康》2011年第9期970-972,共3页Occupation and Health

摘　　要：目的研究甲基丙烯酸甲酯(MMA)对雄性哺乳动物生殖系统的毒性作用。方法通过小鼠精子畸形试验和小鼠睾丸、精囊腺脏器系数的检测,用χ2检验和方差分析的方法对实验数据进行统计分析。结果精子畸形试验的结果显示,MMA的中、高剂量组及阳性对照组与阴性对照组比较,差异均有统计学意义(P<0.01);而低剂量组与阴性对照组比较,差异无统计学意义(P>0.05)。在睾丸脏器系数的检测中,低、中、高剂量组及阳性对照组与阴性对照组比较,差异均无统计学意义(P>0.05)。在植囊腺脏器系数的检测中,高剂量组及阳性对照组与阴性对照组比较,差异有统计学意义(P<0.05);而低、中剂量组与阴性组比较未发现差异有统计学意义(P>0.05)。结论提示MMA可能对雄性哺乳动物的生殖系统有毒性作用。[Objective]To study the toxic effect of methyl methacrylate（MMA） to reproductive system of the male mammals.[Methods]Through sperm shape abnormality test of the rats and the examinations of the testicular and seminal vesicle＇ s viscera coefficient in the male rats,the experimental data were analyzed by the methods of χ2test and variance analysis.[Results]The results of sperm shape abnormality test showed,there was significant difference between the medium and high dose group of MMA and the negative control group（P0.01）,while there was no significant difference between the low dose group and the negative control group（P0.05）.In the test of the testicular viscera coefficient,comparing the 5 groups,no difference was found（P0.05）.In the test of the seminal vesicle＇ s viscera coefficient,comparing the high,medium and low dose groups with positive and negative control groups,the differences were not significant（P0.05）.In the test of seminal vesicle＇ s viscera coefficient,there was no significant difference between high dose group,positive control group and the negative control group（P0.05）,while the difference between low,medium dose groups and negative control group was significant（P0.05）.[Conclusion]It is indicated that MMA has toxic effect to the reproductive system of the male mammals.

关 键 词：甲基丙烯酸甲酯 生殖毒性 精于畸形试验 脏器系数 

分 类 号：R114[医药卫生—卫生毒理学]