云克和^(89)Sr联合应用在骨转移癌治疗中的价值  

Value of ^(99)Tc-MDP Combining with ^(89)Sr in Therapy of Osseous Metastasis in Patients with Tumor

作　　者：于仁波[1] 孙振秀 王青民[1] 

机构地区：[1]青岛市肿瘤医院核医学科,山东青岛266042 [2]山东省青岛市中心血站

出　　处：《肿瘤防治研究》2011年第4期455-457,共3页Cancer Research on Prevention and Treatment

摘　　要：目的观察云克和89Sr联合治疗骨转移癌性疼痛的效果。方法对120例确认为骨转移癌患者首先静注89Sr 3mci,一周后,静脉滴注云克22 mg/d,连续10 d,每月一疗程,连用3～6月;89Sr每隔3～4月应用1次,最多用3次。结果止痛效果明显107例,有效8例,无效5例,有效率96%(多在2～3周内获效);止痛时间最长达一年半以上;骨髓抑制极少;部分骨质破坏者明显修复。结论云克和89Sr联合应用对骨转移癌引起的疼痛有很好的治疗和止痛效果;对骨转移癌引起的骨质破坏有明显的修复作用;骨转移患者应及早应用云克和89Sr联合治疗。Objective To investigate the therapeutic efficacy of 99Tc-MDP combining with 89Sr in alleviating pain of patients with osseous metastasis.Methods 89Sr 3mci was intravenously injected into 120 patients with osseous metastasis,after a week,99Tc-MDP,22mg/d,was intravenously injected for 10 days.One course of treatment was one month and was carried on 3 to 6 months;89Sr was used in every 3 to 4 months,three times at most.Results The pain was significant relieved in 107 patients,relieved in 8 patients,and inefficient in 5 patients.The effective power was 96%（relieve in 2 or 3 weeks）;The time extended more than a year and a half.Myelosuppression was occured in few patient;Some patients with destruction of bone were obviously recovered.Conclusion There are conspicuous effect of 99Tc-MDP combining with 89Sr in therapying patients with osseous metastasis and conspicuous recovery for destruction of bone induced by osseous metastasis;Patients with osseous metastasis should be treated with 99Tc-MDP combining with 89Sr at an early date.

关 键 词：骨转移癌 云克 89Sr 止痛 修复 

分 类 号：R817.8[医药卫生—影像医学与核医学] R730.55[医药卫生—放射医学]