HPV分型检测分析及其在宫颈病变中的意义  

Significance of HPV Genotypes in Cervical Lesions

作　　者：杜趁香[1] 王焱[1] 

机构地区：[1]河南科技大学第一附属医院妇科,河南洛阳471003

出　　处：《肿瘤防治研究》2011年第4期458-459,464,共3页Cancer Research on Prevention and Treatment

摘　　要：目的探讨人乳头瘤病毒(human papilloma virus,HPV)21种基因型分型检测及其临床意义。方法对我院因宫颈病变就诊的1 540位女性进行HPV基因分型检测,比较不同基因型与临床疾病的特点。结果本组资料中总的HPV感染率为31.8%(489/1 540),共检出21种基因亚型,高危型最常见类型为HPV16、58、31,低危型最常见类型为HPV6、11。不同年龄段HPV感染率最高的为小于40岁组。HPV感染阳性组宫颈病变及宫颈癌患病率明显高于阴性组。结论 HPV亚型感染与宫颈病变的不同程度关系密切,为宫颈癌的筛查、防治提供理论依据。Objective To study the 21 genotypes of human papilloma virus（HPV） and its clinical significance.Methods 1 540 females with cervical disease were carried through HPV typing in all 21 genotypes in our hospital,then comparing the different genotypes and clincal disease feature.Results The total positive rate was 31.8%（489/1 540）,21 isoforms were checked out,HPV16,58,31 were seen mostly in high risk and HPV6,11 were seen mostly in low risk.Among the positive rates in different stage of years,the less than 40 years old group was the highest.Positive for HPV infection in cervical lesions and cervical carcinoma prevalence was significantly higher than that in the negative group.Conclusion Infection of HPV genotypes are related closely with cervical different-grade lesions,which may apply reasonable evidences for screening,prevention and cure of cervical carcinoma.

关 键 词：HPV基因型 宫颈病变 宫颈癌 

分 类 号：R711.74[医药卫生—妇产科学]