叶酸和维生素B_(12)对糖尿病肾病患者氧化应激水平的影响  

The Effect of Folic Acid and Vitamin B_(12) on Oxidative Stress in Patients with Diabetic Nephropathy

作　　者：罗惠辛[1] 郭沛艳[1] 宋淑萍[1] 窦若兰 胡若梅 王娟[1] 张向英[1] 

机构地区：[1]天津市天和医院内分泌科,300050

出　　处：《天津医药》2011年第4期329-331,共3页Tianjin Medical Journal

摘　　要：目的:探讨叶酸(FA)、维生素B1(2VitB12)干预对糖尿病肾病(DN)患者血浆同型半胱氨酸(Hcy)和氧化应激的影响,从而提供治疗DN的有效治疗方法。方法:将40例DN患者随机分为DN1组和DN2组,DN1组仅给予常规治疗,DN2组在常规治疗的基础上给予FA5mg和VitB12500μg每日3次,干预时间为2周。测定治疗前后的血糖、Hcy、FA、VitB12、血清丙二醛(MDA)、超氧化物歧化酶(SOD)、一氧化氮(NO)、肾功能、肝功能、总胆固醇(CHO)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、24h尿微量白蛋白。结果:(1)治疗后,DN1组FA、VitB12、Hcy无明显变化,DN2组FA、VitB12上升,Hcy水平下降(P<0.01),DN1组和DN2组血糖、MDA、24h尿微量白蛋白定量较干预前下降,NO、SOD较干预前升高(P<0.01)。(2)DN2组MDA、NO、SOD、24h尿微量白蛋白变化幅度高于DN1组(P<0.05)。结论:补充FA、VitB12可降低同型半胱氨酸,降低DN患者体内的氧化应激水平,可能是治疗DN的有效措施。Objective： To investigate the effect of folic acid （FA） and vitamin （Vit） B12 on the high homocysteine （Hcy） and oxidative stress in patients with diabetic nephropathy （DN）. Methods： Forty patients with DN were randomly divided into two groups, DN1 and DN2 groups. Patients in DN2 group were treated with FA （5 mg） and VitB12 （500 μg） three times a day for 2 weeks in addition to routine treatment, and patients in DN1 group received conventional treatment alone. The levels of plasma glucose, Hcy, FA, VitB12, malonaldehyde （MDA）, superoxide dismutase （SOD）, nitrogen monoxidum （NO）, total cholesterol （CHO）, triglyceride （TG）, low density lipoprotein-cholesterol （LDL-C）, high density lipoprotein-cholesterol （HDL-C） and 24-h urinary protein excretion were detected before and after treatment. Results： （1） At the end of two-week after treatment, there were no changes in levels of FA, VitB12 and Hcy in DN1 group. The levels of FA, VitB12 increased and Hcy decreased significantly in DN2 group （P 0.01）. The levels of plasma glucose, MDA and 24-h urinary protein excretion decreased after treatment in DN1 and DN2 groups. But the levels of NO and SOD increased after treatment in DN1 and DN2 groups （P 0.01）. （2） Changes in the level of MAD, NO, SOD and 24-h urinary protein excretion were higher in DN2 group than those of DN1 group （P 0.01）. Conclusion： The treatment with FA and VitB12 can play an effective role in reducing the level of plasma Hcy, and anti-oxidative stress in diabetic nephropathy.

关 键 词：叶酸 维生素B12 半胱氨酸 糖尿病肾病 氧化性应激 

分 类 号：R654.2[医药卫生—外科学]