慢性阻塞性肺病患者运动中生理死腔与潮气量比值变化  

Dead space/tidal volume ratio change during exercise in patients with COPD

作　　者：郑翠霞[1] 徐凤珍[1] 王爱华 

机构地区：[1]蚌埠医学院附属医院肺科,233004

出　　处：《蚌埠医学院学报》1999年第6期391-393,共3页Journal of Bengbu Medical College

摘　　要：目的：探讨慢性阻塞性肺病（ Ｃ Ｏ Ｐ Ｄ） 患者运动中生理死腔量（ Ｖ Ｄ） 及其与潮气量（ Ｖ Ｔ） 比值（ Ｖ Ｄ／ Ｖ Ｔ） 的变化与临床意义。方法：无创性方法测定 Ｃ Ｏ Ｐ Ｄ 和健康对照者静息与运动时潮气末二氧化碳分压（ Ｐｅｔ Ｃ Ｏ２） ，自动计算出 Ｖ Ｄ 及 Ｖ Ｄ／ Ｖ Ｔ 比值。结果： Ｃ Ｏ Ｐ Ｄ 组运动能力与运动中最大通气量（ Ｖ Ｅｍａｘ） 、最大摄氧量（ Ｖ Ｏ２ ｍａｘ） 、最大潮气量（ Ｖ Ｔｍａｘ） 、通气储备量（ Ｂ Ｒ）均较对照组低。两组 Ｖ Ｄ 运动后均显著增高，组间运动前与运动后差异均无显著性； Ｖ Ｄ／ Ｖ Ｔ 值运动后均显著降低，但 Ｃ Ｏ Ｐ Ｄ组降低程度较小，运动后显著高于对照组。运动后动脉血ｐ Ｈ 值明显下降。结论： Ｃ Ｏ Ｐ Ｄ 缓解期患者运动中 Ｖ Ｄ 变化与健康对照组差异无显著性， Ｖ Ｄ／ Ｖ Ｔ 比值的异常主要由 Ｖ Ｔｍａｘ 增加受限引起。Objective:To study the change in ratio of physiological dead space(VD) to tidal volume(VT) during exercise in patients with chronic obstructive pulmonary disease(COPD) and healthy controls.Methods:End tidal CO\-2 pressures(PetCO\-2) were measured with sensormedics NO.2900 system at rest and at the end of exercise in 20 COPD patients and 20 healthy controls.VD and VD/VT were calculated according to Jones' equation.Results:Maximal ventilation(VEmax),Maximal oxygen uptake(VO\-2max),Maximal tidal volume(VTmax) and breathing reserve(BR) were lower in COPD group than those in control group( P <0.01).VD increased significantly at the end of exercise in both 2 groups,but the difference between the 2 groups either at rest or at the end of exercise were not significant.VD/VT ratio decreased significantly after exercise,in both groups the decrease was smaller in COPD group,made VD/VT significantly higher than that of the control group after exercise.The pH of arterial blood decreased significantly.Conclusions:The diffevence in changes of VD during exercise is not significant between the 2 groups.The abnormal response of VD/VT during exercise is mainly due to the restriction of VTmax.

关 键 词：运动试验 生理死腔 阻塞性肺疾病 潮气量 

分 类 号：R563[医药卫生—呼吸系统]