绝经后Ⅱ型糖尿病患者雌激素受体的变化  

Estradiol receptor level in postmenopausal non insulin dependent diabetes mellitus patients

作　　者：石莹[1] 李文君[1] 顾耀[1] 魏霞芳[1] 滕小洪[1] 吴增常[1] 

机构地区：[1]上海上海铁路局中心医院内分泌代谢研究室,200072

出　　处：《蚌埠医学院学报》1999年第6期406-407,共2页Journal of Bengbu Medical College

摘　　要：目的：探讨雌二醇受体（ Ｅ Ｒ） 数量与绝经后Ⅱ型糖尿病的关系。方法：选测绝经后Ⅱ型糖尿病患者４２ 例和６０ 例正常妇女（ 绝经前后各３０ 例） 。采用放射配体法检测外周血白细胞 Ｅ Ｒ 含量；采用放射免疫法检测血浆雌二醇（ Ｅ２） 浓度。结果：绝经后Ⅱ型糖尿病患者组白细胞 Ｅ Ｒ 及血浆 Ｅ２ 显著低于正常绝经前组（ Ｐ＜ ０ ．０１） ，且较正常绝经后组也明显下降（ Ｐ＜ ０ ．０１） 。结论：绝经后Ⅱ型糖尿病的发病可能与雌二醇及 Ｅ Ｒ 的降低有关。Objective:To study the relations between estradiol receptor(ER) level and postmenopausal non insulin dependent diabetes mellitus(NIDDM).Methods:In 42 women with postmenopausal NIDDM(group A) and 30 normal controls after menopause(group B) and 30 normal controls before menopause(group C) the ER contents on white blood cells and plasma estradiol(E\-2) concentrations were measured with radioimmunoassay.Results:Not only the E\-2 and ER in group A were very remarkably lower than those in group C( P <0.01),but were also apparently lower than those in group B( P <0.01).Conclusions:The reduction of E\-2 and ER is responsible for the incidence of postmenopausal NIDDM.

关 键 词：糖尿病 受体 雌激素 绝经后 Ⅱ型 

分 类 号：R588.06[医药卫生—内分泌] R587.202[医药卫生—内科学]