维生素D干预治疗对肥胖及相关代谢异常的影响  

Effects of vitamin D intervention on obesity and its related metabolic disorders

作　　者：尹晓[1] 阎玲[2] 陆勇[1] 

机构地区：[1]山东大学附属济南市中心医院内分泌科,济南250013 [2]山东大学附属济南市中心医院干部保健科,济南250013

出　　处：《山东大学学报（医学版）》2011年第3期1-4,12,共5页Journal of Shandong University:Health Sciences

基　　金：济南青年科技明星计划资助项目(20090110)

摘　　要：目的选择我国北方地区的中年肥胖人群,研究超重肥胖人群维生素D缺乏与肥胖相关代谢异常的关系及维生素D干预治疗的影响。方法在健康查体人员中入选肥胖者201例,按照是否合并代谢综合症分为单纯性肥胖组和肥胖并代谢综合症组,比较两组血清25-OH-VitD水平及各代谢指标与血清25-OH-VitD的相关关系。肥胖并代谢综合症组中有88例合并维生素D缺乏,随机分为干预治疗组和对照组,两组均接受12周的生活方式干预减轻体质量,干预治疗组同时口服维生素D和钙剂,观察干预前后代谢指标的变化。结果单纯性肥胖组和肥胖并代谢综合症组血清25-OH-VitD水平无明显差异(P>0.05),体质量指数(body mass index,BMI)、血甘油三酯与血清25-OH-VitD水平显著相关(P<0.05)。肥胖患者体质量减轻过程中,补充维生素D和钙剂对改善血甘油三酯水平有独立的贡献(P<0.05)。结论我国超重肥胖人群维生素D水平与BMI和血甘油三酯相关,且在减轻体质量过程中,维生素D干预可以进一步改善肥胖症患者的血脂异常。Objective To investigate the relationship between 25-OH-VitD and obesity related metabolic disorders,and determine the effect of vitamin D supplementation on the disorders.Methods A cohort of 201 obese subjects was divided into the obesity group and the obesity with metabolic syndrome group.Height and weight were measured,and body mass indexes（BMI） were calculated.Levels of triglycerides（TG）,high density lipoprotein cholesterol（HDL-C） and fasting plasma glucose were determined.Serum 25-OH-VitD and fasting insulin concentrations were measured by radioimmunoassay.88 obese subjects with metabolic syndrome complicated by vitamin D deficiency were subdivided into the treatment group and the control group.Both groups received life style intervention for weight loss for 12 weeks.At the same time,the treatment group received oral administration of vitamin D.The level of serum 25-OH-VitD and metabolic parameters were measured at the baseline and after the treatment.Results There was no significant difference in the level of serum 25-OH-VitD between the obesity group and the obesity with metabolic syndrome group（P0.05）.The level of serum 25-OH-VitD has a significantly negative association with individual BMI and triglyceride level（P0.05）.After 12-week intervention,a significant decrease in triglyceride level was observed in the treatment group compared with the control group（P0.05）.Conclusions Hypovitaminosis D is associated with BMI and triglyceride level in overweight/obese subjects in China,and the vitamin D supplementation can enhance the beneficial effect of weight loss on lipid disorders in overweight/obese subjects with metabolic syndrome.

关 键 词：肥胖症 维生素D 代谢综合症 

分 类 号：R589.2[医药卫生—内分泌]