老年癌痛与抑郁的相关性及其对免疫功能的影响研究  

Correlation between Pain and Depression and Their Effect on Immune Function in Elderly Cancer Patients

作　　者：沈丽达[1,2] 杨静[1,2] 李云霞[1,2] 杨继岚[1,2] 龙庭凤[1,2] 

机构地区：[1]云南省肿瘤医院 [2]昆明医学院第三附属医院云南省肿瘤研究所肿瘤化疗研究中心,云南昆明650118

出　　处：《昆明医学院学报》2011年第2期34-37,共4页Journal of Kunming Medical College

基　　金：民政部中国老年学学会立项课题(民人教科字(2007)18-2-28)

摘　　要：目的探讨老年癌痛与抑郁的相关性,以及疼痛、抑郁对免疫功能的影响.方法对经病理确诊的老年癌症并伴有疼痛的患者进行抑郁自评量表问卷调查,同时采集血清进行免疫功能测定,并与无疼痛的老年癌症患者比较.结果有疼痛与无疼痛的两组患者抑郁的发生无统计学意义(P>0.05),但疼痛与抑郁程度有相关性,老年癌痛患者重度抑郁的发生率较高(P<0.05);有疼痛与无疼痛的两组患者NK细胞比较有统计学意义(P<0.05),CD3+、CD4+、CD8+比较无明显统计学意义;抑郁组与无抑郁组免疫功能无统计学意义(P>0.05).结论老年癌症患者疼痛与抑郁的发生无相关性,与抑郁程度有相关性,对NK细胞有影响,对CD3+、CD4+、CD8+无明显影响;老年癌痛患者重度抑郁的发生率较高,对免疫功能无影响.Objective To explore the correlation between cancer pain and depression in elderly patients, and the effect of pain and depression on immune function. Methods 49 elderly cancer patients with pain and 60 aged cancer patients without pain controls （diagnosed by pathology） were tested with Self Rating Depression scale （SDS） , Simultaneous venous blood samples were collected from all of the 109 patients for measurement of immune flmction. Results There were no obvious statistical differences in the incidence rate of depression between cancer pain group and cancer pain-free group （P 〉 0.05 ）. But, the degree of depression had significant relationship with pain （P 〈 0.05） , The incidence rate of severe depression was higher in elderly patients with cancer pain than the pain free ones. NK cells had an obvious statistical difference between pain and pain-free patients （P〈 0.036） , however, CD3＋, CD4＋, CD8＋ showed no significant statistical differences. The impact of depression on immune function was not significant （P 〈 0.05）. Conclusions Among the elderly cancer patients, there is no correlation between pain and depression, but the degree of depression has a positive correlation with pain.The incidence rate of sever depression is higher in elderly cancer patients with pain.Moreover, pain has effect on NK cells, but has no effect on CD3＋, CD4＋, CD8＋ cells in elderly cancer patients. Depression has no effect on immune function in in elderly cancer patients.

关 键 词：老年癌痛 抑郁 免疫功能 

分 类 号：R730.231.5[医药卫生—肿瘤]